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Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG.
Rankovic Z, Cai J, Kerr J, Fradera X, Robinson J, Mistry A, Finlay W, McGarry G, Andrews F, Caulfield W, Cumming I, Dempster M, Waller J, Arbuckle W, Anderson M, Martin I, Mitchell A, Long C, Baugh M, Westwood P, Kinghorn E, Jones P, Uitdehaag JC, van Zeeland M, Potin D, Saniere L, Fouquet A, Chevallier F, Deronzier H, Dorleans C, Nicolai E. Rankovic Z, et al. Among authors: anderson m. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6237-41. doi: 10.1016/j.bmcl.2010.08.101. Epub 2010 Aug 24. Bioorg Med Chem Lett. 2010. PMID: 20843687
An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials.
Tse EG, Aithani L, Anderson M, Cardoso-Silva J, Cincilla G, Conduit GJ, Galushka M, Guan D, Hallyburton I, Irwin BWJ, Kirk K, Lehane AM, Lindblom JCR, Lui R, Matthews S, McCulloch J, Motion A, Ng HL, Öeren M, Robertson MN, Spadavecchio V, Tatsis VA, van Hoorn WP, Wade AD, Whitehead TM, Willis P, Todd MH. Tse EG, et al. Among authors: anderson m. J Med Chem. 2021 Nov 25;64(22):16450-16463. doi: 10.1021/acs.jmedchem.1c00313. Epub 2021 Nov 8. J Med Chem. 2021. PMID: 34748707 Free article.
Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators.
Thissera B, Hallyburton I, Ngwa CJ, Cherif-Silini H, Hassane ASI, Anderson M, Campbell LA, Mutter N, Eshelli M, Abdelmohsen UR, Yaseen M, Pradel G, Belbahri L, Elgendy B, Hegazy L, Rateb ME. Thissera B, et al. Among authors: anderson m. Bioorg Chem. 2021 Oct;115:105215. doi: 10.1016/j.bioorg.2021.105215. Epub 2021 Jul 29. Bioorg Chem. 2021. PMID: 34358799
Escaping from Flatland: Antimalarial Activity of sp3-Rich Bridged Pyrrolidine Derivatives.
Cox B, Duffy J, Zdorichenko V, Bellanger C, Hurcum J, Laleu B, Booker-Milburn KI, Elliott LD, Robertson-Ralph M, Swain CJ, Bishop SJ, Hallyburton I, Anderson M. Cox B, et al. Among authors: anderson m. ACS Med Chem Lett. 2020 Nov 10;11(12):2497-2503. doi: 10.1021/acsmedchemlett.0c00486. eCollection 2020 Dec 10. ACS Med Chem Lett. 2020. PMID: 33335673 Free PMC article.
8,255 results