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22 results

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Page 1
Piperidine-based renin inhibitors: upper chain optimization.
Corminboeuf O, Bezençon O, Remeň L, Grisostomi C, Richard-Bildstein S, Bur D, Prade L, Strickner P, Hess P, Fischli W, Steiner B, Treiber A. Corminboeuf O, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6291-6. doi: 10.1016/j.bmcl.2010.08.087. Epub 2010 Aug 22. Bioorg Med Chem Lett. 2010. PMID: 20843690
Inhibitors of Plasmepsin II-potential antimalarial agents.
Corminboeuf O, Dunet G, Hafsi M, Grimont J, Grisostomi C, Meyer S, Binkert C, Bur D, Jones A, Prade L, Brun R, Boss C. Corminboeuf O, et al. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6194-9. doi: 10.1016/j.bmcl.2006.09.027. Epub 2006 Sep 26. Bioorg Med Chem Lett. 2006. PMID: 17000102
Achiral, cheap, and potent inhibitors of Plasmepsins I, II, and IV.
Boss C, Corminboeuf O, Grisostomi C, Meyer S, Jones AF, Prade L, Binkert C, Fischli W, Weller T, Bur D. Boss C, et al. Among authors: corminboeuf o. ChemMedChem. 2006 Dec;1(12):1341-5. doi: 10.1002/cmdc.200600223. ChemMedChem. 2006. PMID: 17091526 No abstract available.
Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.
Bezençon O, Bur D, Weller T, Richard-Bildstein S, Remen L, Sifferlen T, Corminboeuf O, Grisostomi C, Boss C, Prade L, Delahaye S, Treiber A, Strickner P, Binkert C, Hess P, Steiner B, Fischli W. Bezençon O, et al. Among authors: corminboeuf o. J Med Chem. 2009 Jun 25;52(12):3689-702. doi: 10.1021/jm900022f. J Med Chem. 2009. PMID: 19358611
New classes of potent and bioavailable human renin inhibitors.
Remen L, Bezençon O, Richard-Bildstein S, Bur D, Prade L, Corminboeuf O, Boss C, Grisostomi C, Sifferlen T, Strickner P, Hess P, Delahaye S, Treiber A, Weller T, Binkert C, Steiner B, Fischli W. Remen L, et al. Among authors: corminboeuf o. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6762-5. doi: 10.1016/j.bmcl.2009.09.104. Epub 2009 Oct 1. Bioorg Med Chem Lett. 2009. PMID: 19853442
Design and optimization of new piperidines as renin inhibitors.
Corminboeuf O, Bezençon O, Grisostomi C, Remeň L, Richard-Bildstein S, Bur D, Prade L, Hess P, Strickner P, Fischli W, Steiner B, Treiber A. Corminboeuf O, et al. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6286-90. doi: 10.1016/j.bmcl.2010.08.086. Epub 2010 Aug 22. Bioorg Med Chem Lett. 2010. PMID: 20843686
Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action.
Boss C, Aissaoui H, Amaral N, Bauer A, Bazire S, Binkert C, Brun R, Bürki C, Ciana CL, Corminboeuf O, Delahaye S, Dollinger C, Fischli C, Fischli W, Flock A, Frantz MC, Girault M, Grisostomi C, Friedli A, Heidmann B, Hinder C, Jacob G, Le Bihan A, Malrieu S, Mamzed S, Merot A, Meyer S, Peixoto S, Petit N, Siegrist R, Trollux J, Weller T, Wittlin S. Boss C, et al. Among authors: corminboeuf o. ChemMedChem. 2016 Sep 20;11(18):1995-2014. doi: 10.1002/cmdc.201600298. Epub 2016 Jul 29. ChemMedChem. 2016. PMID: 27471138
Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers.
Siegrist R, Pozzi D, Jacob G, Torrisi C, Colas K, Braibant B, Mawet J, Pfeifer T, de Kanter R, Roch C, Kessler M, Moon R, Corminboeuf O, Bezençon O. Siegrist R, et al. Among authors: corminboeuf o. J Med Chem. 2016 Dec 8;59(23):10661-10675. doi: 10.1021/acs.jmedchem.6b01356. Epub 2016 Nov 23. J Med Chem. 2016. PMID: 27933950
Correction to Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers.
Siegrist R, Pozzi D, Jacob G, Torrisi C, Colas K, Braibant B, Mawet J, Pfeifer T, de Kanter R, Roch C, Kessler M, Moon R, Corminboeuf O, Bezençon O. Siegrist R, et al. Among authors: corminboeuf o. J Med Chem. 2017 Mar 9;60(5):2163. doi: 10.1021/acs.jmedchem.7b00219. Epub 2017 Feb 24. J Med Chem. 2017. PMID: 28234473 No abstract available.
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.
Bezençon O, Heidmann B, Siegrist R, Stamm S, Richard S, Pozzi D, Corminboeuf O, Roch C, Kessler M, Ertel EA, Reymond I, Pfeifer T, de Kanter R, Toeroek-Schafroth M, Moccia LG, Mawet J, Moon R, Rey M, Capeleto B, Fournier E. Bezençon O, et al. Among authors: corminboeuf o. J Med Chem. 2017 Dec 14;60(23):9769-9789. doi: 10.1021/acs.jmedchem.7b01236. Epub 2017 Nov 20. J Med Chem. 2017. PMID: 29116786
22 results