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Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy.
Siciliano A, Malpeli G, Platt OS, Lebouef C, Janin A, Scarpa A, Olivieri O, Amato E, Corrocher R, Beuzard Y, De Franceschi L. Siciliano A, et al. Among authors: lebouef c. Haematologica. 2011 Jan;96(1):24-32. doi: 10.3324/haematol.2010.028506. Epub 2010 Sep 17. Haematologica. 2011. PMID: 20851863 Free PMC article.
Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis.
Matte A, De Falco L, Federti E, Cozzi A, Iolascon A, Levi S, Mohandas N, Zamo A, Bruno M, Lebouef C, Janin A, Siciliano A, Ganz T, Federico G, Carlomagno F, Mueller S, Silva I, Carbone C, Melisi D, Kim DW, Choi SY, De Franceschi L. Matte A, et al. Among authors: lebouef c. Antioxid Redox Signal. 2018 Jan 1;28(1):1-14. doi: 10.1089/ars.2017.7051. Epub 2017 Sep 6. Antioxid Redox Signal. 2018. PMID: 28793778
In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell-Related Injury.
Federti E, Matte A, Recchiuti A, Garello F, Ghigo A, El Nemer W, Terreno E, Amoresano A, Mattoscio D, Turrini F, Lebouef C, Janin A, Pantaleo A, Russo R, Marin M, Iatcencko I, Riccardi V, Siciliano A, Iolascon A, Brugnara C, De Franceschi L. Federti E, et al. Among authors: lebouef c. Hemasphere. 2023 Feb 28;7(3):e848. doi: 10.1097/HS9.0000000000000848. eCollection 2023 Mar. Hemasphere. 2023. PMID: 36874380 Free PMC article.
Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of β-thalassemia.
Matte A, Federti E, Winter M, Koerner A, Harmeier A, Mazer N, Tomka T, Di Paolo ML, De Falco L, Andolfo I, Beneduce E, Iolascon A, Macias-Garcia A, Chen JJ, Janin A, Lebouef C, Turrini F, Brugnara C, De Franceschi L. Matte A, et al. Among authors: lebouef c. JCI Insight. 2019 Nov 14;4(22):e130111. doi: 10.1172/jci.insight.130111. JCI Insight. 2019. PMID: 31593554 Free PMC article.