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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit.
Busby RW, Bryant AP, Bartolini WP, Cordero EA, Hannig G, Kessler MM, Mahajan-Miklos S, Pierce CM, Solinga RM, Sun LJ, Tobin JV, Kurtz CB, Currie MG. Busby RW, et al. Among authors: mahajan miklos s. Eur J Pharmacol. 2010 Dec 15;649(1-3):328-35. doi: 10.1016/j.ejphar.2010.09.019. Epub 2010 Sep 20. Eur J Pharmacol. 2010. PMID: 20863829
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract.
Bryant AP, Busby RW, Bartolini WP, Cordero EA, Hannig G, Kessler MM, Pierce CM, Solinga RM, Tobin JV, Mahajan-Miklos S, Cohen MB, Kurtz CB, Currie MG. Bryant AP, et al. Among authors: mahajan miklos s. Life Sci. 2010 May 8;86(19-20):760-5. doi: 10.1016/j.lfs.2010.03.015. Epub 2010 Mar 20. Life Sci. 2010. PMID: 20307554
Plants and animals share functionally common bacterial virulence factors.
Rahme LG, Ausubel FM, Cao H, Drenkard E, Goumnerov BC, Lau GW, Mahajan-Miklos S, Plotnikova J, Tan MW, Tsongalis J, Walendziewicz CL, Tompkins RG. Rahme LG, et al. Among authors: mahajan miklos s. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8815-21. doi: 10.1073/pnas.97.16.8815. Proc Natl Acad Sci U S A. 2000. PMID: 10922040 Free PMC article. Review.
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