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De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation.
Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, Munck S, Van Veldhoven PP, Waltregny D, Daniëls VW, Machiels J, Vanderhoydonc F, Smans K, Waelkens E, Verhoeven G, Swinnen JV. Rysman E, et al. Among authors: brusselmans k. Cancer Res. 2010 Oct 15;70(20):8117-26. doi: 10.1158/0008-5472.CAN-09-3871. Epub 2010 Sep 28. Cancer Res. 2010. PMID: 20876798
Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.
Swinnen JV, Beckers A, Brusselmans K, Organe S, Segers J, Timmermans L, Vanderhoydonc F, Deboel L, Derua R, Waelkens E, De Schrijver E, Van de Sande T, Noël A, Foufelle F, Verhoeven G. Swinnen JV, et al. Among authors: brusselmans k. Cancer Res. 2005 Mar 15;65(6):2441-8. doi: 10.1158/0008-5472.CAN-04-3025. Cancer Res. 2005. PMID: 15781660 Free article.
Increased lipogenesis in cancer cells: new players, novel targets.
Swinnen JV, Brusselmans K, Verhoeven G. Swinnen JV, et al. Among authors: brusselmans k. Curr Opin Clin Nutr Metab Care. 2006 Jul;9(4):358-65. doi: 10.1097/01.mco.0000232894.28674.30. Curr Opin Clin Nutr Metab Care. 2006. PMID: 16778563 Review.
24 results