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De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation.
Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, Munck S, Van Veldhoven PP, Waltregny D, Daniëls VW, Machiels J, Vanderhoydonc F, Smans K, Waelkens E, Verhoeven G, Swinnen JV. Rysman E, et al. Among authors: timmermans l. Cancer Res. 2010 Oct 15;70(20):8117-26. doi: 10.1158/0008-5472.CAN-09-3871. Epub 2010 Sep 28. Cancer Res. 2010. PMID: 20876798
Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.
Swinnen JV, Beckers A, Brusselmans K, Organe S, Segers J, Timmermans L, Vanderhoydonc F, Deboel L, Derua R, Waelkens E, De Schrijver E, Van de Sande T, Noël A, Foufelle F, Verhoeven G. Swinnen JV, et al. Among authors: timmermans l. Cancer Res. 2005 Mar 15;65(6):2441-8. doi: 10.1158/0008-5472.CAN-04-3025. Cancer Res. 2005. PMID: 15781660 Free article.
Accelerated aging during chronic oxidative stress: a role for PARP-1.
Boesten DM, de Vos-Houben JM, Timmermans L, den Hartog GJ, Bast A, Hageman GJ. Boesten DM, et al. Among authors: timmermans l. Oxid Med Cell Longev. 2013;2013:680414. doi: 10.1155/2013/680414. Epub 2013 Nov 10. Oxid Med Cell Longev. 2013. PMID: 24319532 Free PMC article.
Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury.
Jiang J, Mathijs K, Timmermans L, Claessen SM, Hecka A, Weusten J, Peters R, van Delft JH, Kleinjans JCS, Jennen DGJ, de Kok TM. Jiang J, et al. Among authors: timmermans l. Toxicol Appl Pharmacol. 2017 Oct 1;332:100-108. doi: 10.1016/j.taap.2017.07.014. Epub 2017 Jul 18. Toxicol Appl Pharmacol. 2017. PMID: 28733206
223 results