Zhang Q - Search Results

1

Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography.

Wilderman PR, Shah MB, Liu T, Li S, Hsu S, Roberts AG, Goodlett DR, Zhang Q, Woods VL Jr, Stout CD, Halpert JR. Wilderman PR, et al. Among authors: zhang q. J Biol Chem. 2010 Dec 3;285(49):38602-11. doi: 10.1074/jbc.M110.180646. Epub 2010 Sep 28. J Biol Chem. 2010. PMID: 20880847 Free PMC article.

2

Crystal structure of CYP24A1, a mitochondrial cytochrome P450 involved in vitamin D metabolism.

Annalora AJ, Goodin DB, Hong WX, Zhang Q, Johnson EF, Stout CD. Annalora AJ, et al. Among authors: zhang q. J Mol Biol. 2010 Feb 19;396(2):441-51. doi: 10.1016/j.jmb.2009.11.057. Epub 2009 Dec 1. J Mol Biol. 2010. PMID: 19961857 Free PMC article.

3

Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.

Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR. Gay SC, et al. Among authors: zhang q. Mol Pharmacol. 2010 Apr;77(4):529-38. doi: 10.1124/mol.109.062570. Epub 2010 Jan 8. Mol Pharmacol. 2010. PMID: 20061448 Free PMC article.

4

Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.

Gay SC, Roberts AG, Maekawa K, Talakad JC, Hong WX, Zhang Q, Stout CD, Halpert JR. Gay SC, et al. Among authors: zhang q. Biochemistry. 2010 Oct 12;49(40):8709-20. doi: 10.1021/bi100914z. Epub 2010 Sep 15. Biochemistry. 2010. PMID: 20815363 Free PMC article.

5

Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity.

Gay SC, Zhang H, Wilderman PR, Roberts AG, Liu T, Li S, Lin HL, Zhang Q, Woods VL Jr, Stout CD, Hollenberg PF, Halpert JR. Gay SC, et al. Among authors: zhang q, zhang h. Biochemistry. 2011 Jun 7;50(22):4903-11. doi: 10.1021/bi200482g. Epub 2011 May 13. Biochemistry. 2011. PMID: 21510666 Free PMC article.

6

Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains.

Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR. Shah MB, et al. Among authors: zhang q. Mol Pharmacol. 2011 Dec;80(6):1047-55. doi: 10.1124/mol.111.074427. Epub 2011 Aug 29. Mol Pharmacol. 2011. PMID: 21875942 Free PMC article.

7

Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme.

Wilderman PR, Gay SC, Jang HH, Zhang Q, Stout CD, Halpert JR. Wilderman PR, et al. Among authors: zhang q. FEBS J. 2012 May;279(9):1607-20. doi: 10.1111/j.1742-4658.2011.08411.x. Epub 2011 Nov 25. FEBS J. 2012. PMID: 22051155 Free PMC article.

8

Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules.

Shah MB, Wilderman PR, Pascual J, Zhang Q, Stout CD, Halpert JR. Shah MB, et al. Among authors: zhang q. Biochemistry. 2012 Sep 18;51(37):7225-38. doi: 10.1021/bi300894z. Epub 2012 Sep 4. Biochemistry. 2012. PMID: 22909231 Free PMC article.

9

Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis.

Zhang H, Gay SC, Shah M, Foroozesh M, Liu J, Osawa Y, Zhang Q, Stout CD, Halpert JR, Hollenberg PF. Zhang H, et al. Among authors: zhang q. Biochemistry. 2013 Jan 15;52(2):355-64. doi: 10.1021/bi301567z. Epub 2013 Jan 4. Biochemistry. 2013. PMID: 23276288 Free PMC article.

10

X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: insights into compensatory rearrangements of the binding pocket.

Shah MB, Jang HH, Zhang Q, David Stout C, Halpert JR. Shah MB, et al. Among authors: zhang q. Arch Biochem Biophys. 2013 Feb 15;530(2):64-72. doi: 10.1016/j.abb.2012.12.016. Epub 2013 Jan 4. Arch Biochem Biophys. 2013. PMID: 23296089 Free PMC article.

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