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72 results

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Page 1
Towards the discovery of new hypnotic agents: synthesis and preliminary pharmacological evaluation of a novel class of dibenzo[a,d]cycloheptene derivatives.
Castiglioni E, Di Fabio R, Togninelli A, Brough S, Brown F, Dal Cin M, Gianotti M, Marchioro C, Merlo G, Spinosa R, Wigglesworth MJ, Botta M. Castiglioni E, et al. Among authors: brough s. ChemMedChem. 2010 Nov 8;5(11):1843-6. doi: 10.1002/cmdc.201000280. ChemMedChem. 2010. PMID: 20922744 No abstract available.
Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders.
Gianotti M, Botta M, Brough S, Carletti R, Castiglioni E, Corti C, Dal-Cin M, Delle Fratte S, Korajac D, Lovric M, Merlo G, Mesic M, Pavone F, Piccoli L, Rast S, Roscic M, Sava A, Smehil M, Stasi L, Togninelli A, Wigglesworth MJ. Gianotti M, et al. Among authors: brough s. J Med Chem. 2010 Nov 11;53(21):7778-95. doi: 10.1021/jm100856p. J Med Chem. 2010. PMID: 20942472
Use of cryopreserved cells for enabling greater flexibility in compound profiling.
Wigglesworth MJ, Lawless KJ, Standing DJ, Mackenzie EK, Kitchen VR, McKay F, Ward E, Brough SJ, Stylianou M, Jewitt FR, McLaren-Douglas AM, Jowet MI, Tamayama N, Finnigan D, Ding J, Wise A. Wigglesworth MJ, et al. Among authors: brough sj. J Biomol Screen. 2008 Jun;13(5):354-62. doi: 10.1177/1087057108317768. Epub 2008 May 8. J Biomol Screen. 2008. PMID: 18467669
Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists.
Wilson DM, Apps J, Bailey N, Bamford MJ, Beresford IJ, Brackenborough K, Briggs MA, Brough S, Calver AR, Crook B, Davis RK, Davis RP, Davis S, Dean DK, Harris L, Heslop T, Holland V, Jeffrey P, Panchal TA, Parr CA, Quashie N, Schogger J, Sehmi SS, Stean TO, Steadman JG, Trail B, Wald J, Worby A, Takle AK, Witherington J, Medhurst AD. Wilson DM, et al. Among authors: brough s. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6890-6. doi: 10.1016/j.bmcl.2013.09.090. Epub 2013 Oct 5. Bioorg Med Chem Lett. 2013. PMID: 24269482
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
Gunthorpe MJ, Hannan SL, Smart D, Jerman JC, Arpino S, Smith GD, Brough S, Wright J, Egerton J, Lappin SC, Holland VA, Winborn K, Thompson M, Rami HK, Randall A, Davis JB. Gunthorpe MJ, et al. Among authors: brough s. J Pharmacol Exp Ther. 2007 Jun;321(3):1183-92. doi: 10.1124/jpet.106.116657. Epub 2007 Mar 28. J Pharmacol Exp Ther. 2007. PMID: 17392405
SB-334867-A: the first selective orexin-1 receptor antagonist.
Smart D, Sabido-David C, Brough SJ, Jewitt F, Johns A, Porter RA, Jerman JC. Smart D, et al. Among authors: brough sj. Br J Pharmacol. 2001 Mar;132(6):1179-82. doi: 10.1038/sj.bjp.0703953. Br J Pharmacol. 2001. PMID: 11250867 Free PMC article.
1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.
Porter RA, Chan WN, Coulton S, Johns A, Hadley MS, Widdowson K, Jerman JC, Brough SJ, Coldwell M, Smart D, Jewitt F, Jeffrey P, Austin N. Porter RA, et al. Among authors: brough sj. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1907-10. doi: 10.1016/s0960-894x(01)00343-2. Bioorg Med Chem Lett. 2001. PMID: 11459658
72 results