Anand GS - Search Results

1

Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination.

Moorthy BS, Gao Y, Anand GS. Moorthy BS, et al. Among authors: anand gs. Mol Cell Proteomics. 2011 Feb;10(2):M110.002295. doi: 10.1074/mcp.M110.002295. Epub 2010 Oct 5. Mol Cell Proteomics. 2011. PMID: 20923972 Free PMC article.

2

Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase.

Anand GS, Krishnamurthy S, Bishnoi T, Kornev A, Taylor SS, Johnson DA. Anand GS, et al. Mol Cell Proteomics. 2010 Oct;9(10):2225-37. doi: 10.1074/mcp.M900388-MCP200. Epub 2010 Feb 18. Mol Cell Proteomics. 2010. PMID: 20167947 Free PMC article.

3

Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design.

Badireddy S, Yunfeng G, Ritchie M, Akamine P, Wu J, Kim CW, Taylor SS, Qingsong L, Swaminathan K, Anand GS. Badireddy S, et al. Among authors: anand gs. Mol Cell Proteomics. 2011 Mar;10(3):M110.004390. doi: 10.1074/mcp.M110.004390. Epub 2010 Nov 16. Mol Cell Proteomics. 2011. PMID: 21081668 Free PMC article.

4

Multistate allostery in response regulators: phosphorylation and mutagenesis activate RegA via alternate modes.

Moorthy BS, Anand GS. Moorthy BS, et al. Among authors: anand gs. J Mol Biol. 2012 Apr 13;417(5):468-87. doi: 10.1016/j.jmb.2012.01.052. Epub 2012 Feb 7. J Mol Biol. 2012. PMID: 22326871

5

Dynamics of phosphodiesterase-induced cAMP dissociation from protein kinase A: capturing transient ternary complexes by HDXMS.

Krishnamurthy S, Moorthy BS, Liqin L, Anand GS. Krishnamurthy S, et al. Among authors: anand gs. Biochim Biophys Acta. 2013 Jun;1834(6):1215-21. doi: 10.1016/j.bbapap.2013.02.028. Epub 2013 Mar 15. Biochim Biophys Acta. 2013. PMID: 23501673

6

Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.

Krishnamurthy S, Moorthy BS, Xin Xiang L, Xin Shan L, Bharatham K, Tulsian NK, Mihalek I, Anand GS. Krishnamurthy S, et al. Among authors: anand gs. Biophys J. 2014 Sep 16;107(6):1426-40. doi: 10.1016/j.bpj.2014.07.050. Biophys J. 2014. PMID: 25229150 Free PMC article.

7

Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling.

Krishnamurthy S, Tulsian NK, Chandramohan A, Anand GS. Krishnamurthy S, et al. Among authors: anand gs. Biophys J. 2015 Sep 15;109(6):1251-63. doi: 10.1016/j.bpj.2015.06.067. Epub 2015 Aug 11. Biophys J. 2015. PMID: 26276689 Free PMC article.

8

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase.

Ali N, Ling N, Krishnamurthy S, Oakhill JS, Scott JW, Stapleton DI, Kemp BE, Anand GS, Gooley PR. Ali N, et al. Among authors: anand gs. Sci Rep. 2016 Dec 21;6:39417. doi: 10.1038/srep39417. Sci Rep. 2016. PMID: 28000716 Free PMC article.

9

Dissecting Orthosteric Contacts for a Reverse-Fragment-Based Ligand Design.

Chandramohan A, Tulsian NK, Anand GS. Chandramohan A, et al. Among authors: anand gs. Anal Chem. 2017 Aug 1;89(15):7876-7885. doi: 10.1021/acs.analchem.7b00587. Epub 2017 Jul 14. Anal Chem. 2017. PMID: 28628309

10

Channeling of cAMP in PDE-PKA Complexes Promotes Signal Adaptation.

Tulsian NK, Krishnamurthy S, Anand GS. Tulsian NK, et al. Among authors: anand gs. Biophys J. 2017 Jun 20;112(12):2552-2566. doi: 10.1016/j.bpj.2017.04.045. Biophys J. 2017. PMID: 28636912 Free PMC article.

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