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The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.
Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H. Xia X, et al. Among authors: takashima a. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8760-5. doi: 10.1073/pnas.132045399. Epub 2002 Jun 17. Proc Natl Acad Sci U S A. 2002. PMID: 12070348 Free PMC article.
Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain.
Kubo A, Ueda S, Yamane A, Wada-Kakuda S, Narita M, Matsuyama M, Nomori A, Takashima A, Kato T, Onodera O, Goto M, Ito M, Tomiyama T, Mori H, Murayama S, Ihara Y, Misonou H, Miyasaka T. Kubo A, et al. Among authors: takashima a. J Neurosci. 2019 Aug 21;39(34):6781-6797. doi: 10.1523/JNEUROSCI.2845-18.2019. Epub 2019 Jun 24. J Neurosci. 2019. PMID: 31235644 Free PMC article.
Tauopathies and tau oligomers.
Takashima A. Takashima A. J Alzheimers Dis. 2013;37(3):565-8. doi: 10.3233/JAD-130653. J Alzheimers Dis. 2013. PMID: 23948895 Review.
Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.
Planel E, Miyasaka T, Launey T, Chui DH, Tanemura K, Sato S, Murayama O, Ishiguro K, Tatebayashi Y, Takashima A. Planel E, et al. Among authors: takashima a. J Neurosci. 2004 Mar 10;24(10):2401-11. doi: 10.1523/JNEUROSCI.5561-03.2004. J Neurosci. 2004. PMID: 15014115 Free PMC article.
759 results