Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness.
Schaefer TL, Vorhees CV, Williams MT.
Schaefer TL, et al.
Neuroscience. 2009 Dec 29;164(4):1431-43. doi: 10.1016/j.neuroscience.2009.09.059. Epub 2009 Sep 25.
Neuroscience. 2009.
PMID: 19786075
Free PMC article.
These findings were unexpected given that 5-HT depleting drugs given to adult or developing animals result in learning deficits [Mazer C, Muneyyirci J, Taheny K, Raio N, Borella A, Whitaker-Azmitia P (1997) Brain Res 760:68-73; Morford LL, Inman-Wood SL, Gudelsky GA, Williams MT, …
These findings were unexpected given that 5-HT depleting drugs given to adult or developing animals result in learning deficits [Mazer C, Mu …