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Fusion of two distinct peptide exosite inhibitors of Factor VIIa.
Roberge M, Peek M, Kirchhofer D, Dennis MS, Lazarus RA. Roberge M, et al. Among authors: kirchhofer d. Biochem J. 2002 Apr 15;363(Pt 2):387-93. doi: 10.1042/0264-6021:3630387. Biochem J. 2002. PMID: 11931669 Free PMC article.
Albumin binding as a general strategy for improving the pharmacokinetics of proteins.
Dennis MS, Zhang M, Meng YG, Kadkhodayan M, Kirchhofer D, Combs D, Damico LA. Dennis MS, et al. Among authors: kirchhofer d. J Biol Chem. 2002 Sep 20;277(38):35035-43. doi: 10.1074/jbc.M205854200. Epub 2002 Jul 15. J Biol Chem. 2002. PMID: 12119302 Free article.
G., Moran, P., Bullens, S., Bunting, S., Schoenfeld, J., Lowe, D., Lai, J., Rancatore, P., Iverson, M., Lim, A., Chisholm, V., Kelley, R. F., Riederer, M., and Kirchhofer, D. (2001) Thromb. ...
G., Moran, P., Bullens, S., Bunting, S., Schoenfeld, J., Lowe, D., Lai, J., Rancatore, P., Iverson, M., Lim, A., Chisholm, V., Kelley …
Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling.
Kirchhofer D, Yao X, Peek M, Eigenbrot C, Lipari MT, Billeci KL, Maun HR, Moran P, Santell L, Wiesmann C, Lazarus RA. Kirchhofer D, et al. J Biol Chem. 2004 Sep 17;279(38):39915-24. doi: 10.1074/jbc.M404795200. Epub 2004 Jun 24. J Biol Chem. 2004. PMID: 15218027 Free article.
Recently, we reported that the protease-like HGF beta-chain binds to Met with low affinity (Stamos, J., Lazarus, R. A., Yao, X., Kirchhofer, D., and Wiesmann, C. (2004) EMBO J. 23, 2325-2335). Here we demonstrate that the zymogen-like form of HGF beta also binds Met …
Recently, we reported that the protease-like HGF beta-chain binds to Met with low affinity (Stamos, J., Lazarus, R. A., Yao, X., Kirchhof …
A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo.
Olivero AG, Eigenbrot C, Goldsmith R, Robarge K, Artis DR, Flygare J, Rawson T, Sutherlin DP, Kadkhodayan S, Beresini M, Elliott LO, DeGuzman GG, Banner DW, Ultsch M, Marzec U, Hanson SR, Refino C, Bunting S, Kirchhofer D. Olivero AG, et al. Among authors: kirchhofer d. J Biol Chem. 2005 Mar 11;280(10):9160-9. doi: 10.1074/jbc.M409068200. Epub 2005 Jan 4. J Biol Chem. 2005. PMID: 15632123 Free article.
133 results