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Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy.
Abanades S, van der Aart J, Barletta JA, Marzano C, Searle GE, Salinas CA, Ahmad JJ, Reiley RR, Pampols-Maso S, Zamuner S, Cunningham VJ, Rabiner EA, Laruelle MA, Gunn RN. Abanades S, et al. Among authors: laruelle ma. J Cereb Blood Flow Metab. 2011 Mar;31(3):944-52. doi: 10.1038/jcbfm.2010.175. Epub 2010 Oct 13. J Cereb Blood Flow Metab. 2011. PMID: 20940733 Free PMC article.
Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain.
Murthy NV, Selvaraj S, Cowen PJ, Bhagwagar Z, Riedel WJ, Peers P, Kennedy JL, Sahakian BJ, Laruelle MA, Rabiner EA, Grasby PM. Murthy NV, et al. Among authors: laruelle ma. Neuroimage. 2010 Aug 1;52(1):50-4. doi: 10.1016/j.neuroimage.2010.04.032. Epub 2010 Apr 18. Neuroimage. 2010. PMID: 20406689
Modelling: when and why?
Laruelle M. Laruelle M. Eur J Nucl Med. 1999 Jun;26(6):571-2. doi: 10.1007/s002590050423. Eur J Nucl Med. 1999. PMID: 10369941 No abstract available.