Rubinsztein DC - Search Results

1

Regulation of mammalian autophagy in physiology and pathophysiology.

Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, Massey DC, Menzies FM, Moreau K, Narayanan U, Renna M, Siddiqi FH, Underwood BR, Winslow AR, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Physiol Rev. 2010 Oct;90(4):1383-435. doi: 10.1152/physrev.00030.2009. Physiol Rev. 2010. PMID: 20959619 Free article. Review.

2

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy.

Ravikumar B, Duden R, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2002 May 1;11(9):1107-17. doi: 10.1093/hmg/11.9.1107. Hum Mol Genet. 2002. PMID: 11978769

3

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy.

Ravikumar B, Stewart A, Kita H, Kato K, Duden R, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Hum Mol Genet. 2003 May 1;12(9):985-94. doi: 10.1093/hmg/ddg109. Hum Mol Genet. 2003. PMID: 12700167

4

Alpha-Synuclein is degraded by both autophagy and the proteasome.

Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC. Webb JL, et al. Among authors: rubinsztein dc. J Biol Chem. 2003 Jul 4;278(27):25009-13. doi: 10.1074/jbc.M300227200. Epub 2003 Apr 28. J Biol Chem. 2003. PMID: 12719433 Free article.

5

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Nat Genet. 2004 Jun;36(6):585-95. doi: 10.1038/ng1362. Epub 2004 May 16. Nat Genet. 2004. PMID: 15146184

6

Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases.

Webb JL, Ravikumar B, Rubinsztein DC. Webb JL, et al. Among authors: rubinsztein dc. Int J Biochem Cell Biol. 2004 Dec;36(12):2541-50. doi: 10.1016/j.biocel.2004.02.003. Int J Biochem Cell Biol. 2004. PMID: 15325591

7

Can autophagy protect against neurodegeneration caused by aggregate-prone proteins?

Ravikumar B, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Neuroreport. 2004 Nov 15;15(16):2443-5. doi: 10.1097/00001756-200411150-00001. Neuroreport. 2004. PMID: 15538170 Review.

8

Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice.

Davies JE, Wang L, Garcia-Oroz L, Cook LJ, Vacher C, O'Donovan DG, Rubinsztein DC. Davies JE, et al. Among authors: rubinsztein dc. Nat Med. 2005 Jun;11(6):672-7. doi: 10.1038/nm1242. Epub 2005 May 1. Nat Med. 2005. PMID: 15864313

9

Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.

Luo S, Vacher C, Davies JE, Rubinsztein DC. Luo S, et al. Among authors: rubinsztein dc. J Cell Biol. 2005 May 23;169(4):647-56. doi: 10.1083/jcb.200412071. J Cell Biol. 2005. PMID: 15911879 Free PMC article.

10

Dynein mutations impair autophagic clearance of aggregate-prone proteins.

Ravikumar B, Acevedo-Arozena A, Imarisio S, Berger Z, Vacher C, O'Kane CJ, Brown SD, Rubinsztein DC. Ravikumar B, et al. Among authors: rubinsztein dc. Nat Genet. 2005 Jul;37(7):771-6. doi: 10.1038/ng1591. Epub 2005 Jun 26. Nat Genet. 2005. PMID: 15980862

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