Agama K - Search Results

1

A novel DNA topoisomerase I inhibitor with different mechanism from camptothecin induces G2/M phase cell cycle arrest to K562 cells.

Wu N, Wu XW, Agama K, Pommier Y, Du J, Li D, Gu LQ, Huang ZS, An LK. Wu N, et al. Among authors: agama k. Biochemistry. 2010 Nov 30;49(47):10131-6. doi: 10.1021/bi1009419. Epub 2010 Nov 8. Biochemistry. 2010. PMID: 21033700 Free PMC article.

2

Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison.

Antony S, Kohlhagen G, Agama K, Jayaraman M, Cao S, Durrani FA, Rustum YM, Cushman M, Pommier Y. Antony S, et al. Among authors: agama k. Mol Pharmacol. 2005 Feb;67(2):523-30. doi: 10.1124/mol.104.003889. Epub 2004 Nov 5. Mol Pharmacol. 2005. PMID: 15531731

3

Total and semisynthesis and in vitro studies of both enantiomers of 20-fluorocamptothecin.

Tangirala RS, Dixon R, Yang D, Ambrus A, Antony S, Agama K, Pommier Y, Curran DP. Tangirala RS, et al. Among authors: agama k. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4736-40. doi: 10.1016/j.bmcl.2005.07.074. Bioorg Med Chem Lett. 2005. PMID: 16140529

4

Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells.

Brantley E, Antony S, Kohlhagen G, Meng L, Agama K, Stinson SF, Sausville EA, Pommier Y. Brantley E, et al. Among authors: agama k. Cancer Chemother Pharmacol. 2006 Jul;58(1):62-72. doi: 10.1007/s00280-005-0127-z. Epub 2005 Dec 6. Cancer Chemother Pharmacol. 2006. PMID: 16331501

5

Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin.

Tangirala RS, Antony S, Agama K, Pommier Y, Anderson BD, Bevins R, Curran DP. Tangirala RS, et al. Among authors: agama k. Bioorg Med Chem. 2006 Sep 15;14(18):6202-12. doi: 10.1016/j.bmc.2006.05.073. Epub 2006 Jun 21. Bioorg Med Chem. 2006. PMID: 16793274

6

Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity.

Antony S, Agama KK, Miao ZH, Hollingshead M, Holbeck SL, Wright MH, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y. Antony S, et al. Among authors: agama kk. Mol Pharmacol. 2006 Sep;70(3):1109-20. doi: 10.1124/mol.106.024372. Epub 2006 Jun 23. Mol Pharmacol. 2006. PMID: 16798938

7

4-nitroquinoline-1-oxide induces the formation of cellular topoisomerase I-DNA cleavage complexes.

Miao ZH, Rao VA, Agama K, Antony S, Kohn KW, Pommier Y. Miao ZH, et al. Among authors: agama k. Cancer Res. 2006 Jul 1;66(13):6540-5. doi: 10.1158/0008-5472.CAN-05-4471. Cancer Res. 2006. PMID: 16818625

8

Repair of topoisomerase I-mediated DNA damage.

Pommier Y, Barcelo JM, Rao VA, Sordet O, Jobson AG, Thibaut L, Miao ZH, Seiler JA, Zhang H, Marchand C, Agama K, Nitiss JL, Redon C. Pommier Y, et al. Among authors: agama k. Prog Nucleic Acid Res Mol Biol. 2006;81:179-229. doi: 10.1016/S0079-6603(06)81005-6. Prog Nucleic Acid Res Mol Biol. 2006. PMID: 16891172 Free PMC article. Review.

9

Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.

Nagarajan M, Morrell A, Antony S, Kohlhagen G, Agama K, Pommier Y, Ragazzon PA, Garbett NC, Chaires JB, Hollingshead M, Cushman M. Nagarajan M, et al. Among authors: agama k. J Med Chem. 2006 Aug 24;49(17):5129-40. doi: 10.1021/jm060046o. J Med Chem. 2006. PMID: 16913702

10

Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes.

Miao ZH, Agama K, Sordet O, Povirk L, Kohn KW, Pommier Y. Miao ZH, et al. Among authors: agama k. DNA Repair (Amst). 2006 Dec 9;5(12):1489-94. doi: 10.1016/j.dnarep.2006.07.004. Epub 2006 Aug 28. DNA Repair (Amst). 2006. PMID: 16935573

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