Koelsch G - Search Results

1

Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice.

Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J. Chang WP, et al. Among authors: koelsch g. FASEB J. 2011 Feb;25(2):775-84. doi: 10.1096/fj.10-167213. Epub 2010 Nov 8. FASEB J. 2011. PMID: 21059748 Free PMC article.

2

Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.

Turner RT 3rd, Loy JA, Nguyen C, Devasamudram T, Ghosh AK, Koelsch G, Tang J. Turner RT 3rd, et al. Among authors: koelsch g. Biochemistry. 2002 Jul 9;41(27):8742-6. doi: 10.1021/bi025926t. Biochemistry. 2002. PMID: 12093293

3

Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.

He X, Chang WP, Koelsch G, Tang J. He X, et al. Among authors: koelsch g. FEBS Lett. 2002 Jul 31;524(1-3):183-7. doi: 10.1016/s0014-5793(02)03052-1. FEBS Lett. 2002. PMID: 12135764 Free article.

4

Study of memapsin 2 (beta-secretase) and strategy of inhibitor design.

Tang J, Ghosh AK, Hong L, Koelsch G, Turner RT 3rd, Chang W. Tang J, et al. Among authors: koelsch g. J Mol Neurosci. 2003;20(3):299-304. doi: 10.1385/JMN:20:3:299. J Mol Neurosci. 2003. PMID: 14501012 Review.

5

Memapsin 2, a drug target for Alzheimer's disease.

Koelsch G, Turner RT 3rd, Hong L, Ghosh AK, Tang J. Koelsch G, et al. Biochem Soc Symp. 2003;(70):213-20. doi: 10.1042/bss0700213. Biochem Soc Symp. 2003. PMID: 14587294 Review.

6

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors.

Chang WP, Koelsch G, Wong S, Downs D, Da H, Weerasena V, Gordon B, Devasamudram T, Bilcer G, Ghosh AK, Tang J. Chang WP, et al. Among authors: koelsch g. J Neurochem. 2004 Jun;89(6):1409-16. doi: 10.1111/j.1471-4159.2004.02452.x. J Neurochem. 2004. PMID: 15189343 Free article.

7

Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.

Huang XP, Chang WP, Koelsch G, Turner RT 3rd, Lupu F, Tang J. Huang XP, et al. Among authors: koelsch g. J Biol Chem. 2004 Sep 3;279(36):37886-94. doi: 10.1074/jbc.M402130200. Epub 2004 Jun 14. J Biol Chem. 2004. PMID: 15197182 Free article.

8

Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).

Turner RT 3rd, Hong L, Koelsch G, Ghosh AK, Tang J. Turner RT 3rd, et al. Among authors: koelsch g. Biochemistry. 2005 Jan 11;44(1):105-12. doi: 10.1021/bi048106k. Biochemistry. 2005. PMID: 15628850

9

Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design.

Turner RT 3rd, Koelsch G, Hong L, Castanheira P, Ermolieff J, Ghosh AK, Tang J. Turner RT 3rd, et al. Among authors: koelsch g. Biochemistry. 2001 Aug 28;40(34):10001-6. doi: 10.1021/bi015546s. Biochemistry. 2001. PMID: 11513577

10

Memapsin 2 (beta-secretase) as a therapeutic target.

Hong L, Turner RT 3rd, Koelsch G, Ghosh AK, Tang J. Hong L, et al. Among authors: koelsch g. Biochem Soc Trans. 2002 Aug;30(4):530-4. doi: 10.1042/bst0300530. Biochem Soc Trans. 2002. PMID: 12196130 Review.

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