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Inverse agonism and the regulation of receptor number.
Milligan G, Bond RA. Milligan G, et al. Trends Pharmacol Sci. 1997 Dec;18(12):468-74. doi: 10.1016/s0165-6147(97)01139-5. Trends Pharmacol Sci. 1997. PMID: 9458695 Review.
Inverse agonists are ligands that preferentially stabilize inactive conformations of G protein-coupled receptors. In a range of systems, sustained treatment with inverse agonists can produce substantially greater upregulation of receptor levels than antagonists. The use of …
Inverse agonists are ligands that preferentially stabilize inactive conformations of G protein-coupled receptors. In a range of syste …
GPCR dimerisation.
Milligan G, Ramsay D, Pascal G, Carrillo JJ. Milligan G, et al. Life Sci. 2003 Dec 5;74(2-3):181-8. doi: 10.1016/j.lfs.2003.09.005. Life Sci. 2003. PMID: 14607245 Review.
793 results