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Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.
Simón AM, Schiapparelli L, Salazar-Colocho P, Cuadrado-Tejedor M, Escribano L, López de Maturana R, Del Río J, Pérez-Mediavilla A, Frechilla D. Simón AM, et al. Among authors: salazar colocho p. Neurobiol Dis. 2009 Mar;33(3):369-78. doi: 10.1016/j.nbd.2008.11.005. Epub 2008 Nov 28. Neurobiol Dis. 2009. PMID: 19101630 Free article.