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Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.
Wang C, Hockerman S, Jacobsen EJ, Alippe Y, Selness SR, Hope HR, Hirsch JL, Mnich SJ, Saabye MJ, Hood WF, Bonar SL, Abu-Amer Y, Haimovich A, Hoffman HM, Monahan JB, Mbalaviele G. Wang C, et al. Among authors: hoffman hm. J Exp Med. 2018 May 7;215(5):1315-1325. doi: 10.1084/jem.20172063. Epub 2018 Mar 16. J Exp Med. 2018. PMID: 29549113 Free PMC article.
Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome.
Stackowicz J, Gaudenzio N, Serhan N, Conde E, Godon O, Marichal T, Starkl P, Balbino B, Roers A, Bruhns P, Jönsson F, Moguelet P, Georgin-Lavialle S, Broderick L, Hoffman HM, Galli SJ, Reber LL. Stackowicz J, et al. Among authors: hoffman hm. J Exp Med. 2021 Oct 4;218(10):e20201466. doi: 10.1084/jem.20201466. Epub 2021 Sep 3. J Exp Med. 2021. PMID: 34477811 Free PMC article.
Long-term exposure to house dust mites accelerates lung cancer development in mice.
Wang D, Li W, Albasha N, Griffin L, Chang H, Amaya L, Ganguly S, Zeng L, Keum B, González-Navajas JM, Levin M, AkhavanAghdam Z, Snyder H, Schwartz D, Tao A, Boosherhri LM, Hoffman HM, Rose M, Estrada MV, Varki N, Herdman S, Corr M, Webster NJG, Raz E, Bertin S. Wang D, et al. Among authors: hoffman hm. J Exp Clin Cancer Res. 2023 Jan 21;42(1):26. doi: 10.1186/s13046-022-02587-9. J Exp Clin Cancer Res. 2023. PMID: 36670473 Free PMC article.
NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury.
Yamasaki K, Muto J, Taylor KR, Cogen AL, Audish D, Bertin J, Grant EP, Coyle AJ, Misaghi A, Hoffman HM, Gallo RL. Yamasaki K, et al. Among authors: hoffman hm. J Biol Chem. 2009 May 8;284(19):12762-71. doi: 10.1074/jbc.M806084200. Epub 2009 Mar 3. J Biol Chem. 2009. PMID: 19258328 Free PMC article.
187 results