Kumar K - Search Results

1

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

Kumar K, Awasthi D, Lee SY, Zanardi I, Ruzsicska B, Knudson S, Tonge PJ, Slayden RA, Ojima I. Kumar K, et al. J Med Chem. 2011 Jan 13;54(1):374-81. doi: 10.1021/jm1012006. Epub 2010 Dec 2. J Med Chem. 2011. PMID: 21126020 Free PMC article.

2

Discovery of anti-TB agents that target the cell-division protein FtsZ.

Kumar K, Awasthi D, Berger WT, Tonge PJ, Slayden RA, Ojima I. Kumar K, et al. Future Med Chem. 2010 Aug;2(8):1305-23. doi: 10.4155/fmc.10.220. Future Med Chem. 2010. PMID: 21339840 Free PMC article. Review.

3

Therapeutic potential of FtsZ inhibition: a patent perspective.

Awasthi D, Kumar K, Ojima I. Awasthi D, et al. Among authors: kumar k. Expert Opin Ther Pat. 2011 May;21(5):657-79. doi: 10.1517/13543776.2011.568483. Epub 2011 Mar 18. Expert Opin Ther Pat. 2011. PMID: 21413908 Review.

4

Benzimidazole-based antibacterial agents against Francisella tularensis.

Kumar K, Awasthi D, Lee SY, Cummings JE, Knudson SE, Slayden RA, Ojima I. Kumar K, et al. Bioorg Med Chem. 2013 Jun 1;21(11):3318-26. doi: 10.1016/j.bmc.2013.02.059. Epub 2013 Apr 3. Bioorg Med Chem. 2013. PMID: 23623254 Free PMC article.

5

SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents.

Awasthi D, Kumar K, Knudson SE, Slayden RA, Ojima I. Awasthi D, et al. Among authors: kumar k. J Med Chem. 2013 Dec 12;56(23):9756-70. doi: 10.1021/jm401468w. Epub 2013 Nov 23. J Med Chem. 2013. PMID: 24266862 Free PMC article.

6

Drug discovery targeting cell division proteins, microtubules and FtsZ.

Ojima I, Kumar K, Awasthi D, Vineberg JG. Ojima I, et al. Among authors: kumar k. Bioorg Med Chem. 2014 Sep 15;22(18):5060-77. doi: 10.1016/j.bmc.2014.02.036. Epub 2014 Mar 5. Bioorg Med Chem. 2014. PMID: 24680057 Free PMC article. Review.

7

Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents.

Park B, Awasthi D, Chowdhury SR, Melief EH, Kumar K, Knudson SE, Slayden RA, Ojima I. Park B, et al. Among authors: kumar k. Bioorg Med Chem. 2014 May 1;22(9):2602-12. doi: 10.1016/j.bmc.2014.03.035. Epub 2014 Apr 1. Bioorg Med Chem. 2014. PMID: 24726304 Free PMC article.

8

A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis.

Knudson SE, Awasthi D, Kumar K, Carreau A, Goullieux L, Lagrange S, Vermet H, Ojima I, Slayden RA. Knudson SE, et al. Among authors: kumar k. PLoS One. 2014 Apr 15;9(4):e93953. doi: 10.1371/journal.pone.0093953. eCollection 2014. PLoS One. 2014. PMID: 24736743 Free PMC article.

9

In vitro-in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis.

Knudson SE, Kumar K, Awasthi D, Ojima I, Slayden RA. Knudson SE, et al. Among authors: kumar k. Tuberculosis (Edinb). 2014 May;94(3):271-6. doi: 10.1016/j.tube.2014.03.007. Epub 2014 Apr 1. Tuberculosis (Edinb). 2014. PMID: 24746463 Free PMC article.

10

Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model.

Knudson SE, Awasthi D, Kumar K, Carreau A, Goullieux L, Lagrange S, Vermet H, Ojima I, Slayden RA. Knudson SE, et al. Among authors: kumar k. J Antimicrob Chemother. 2015 Nov;70(11):3070-3. doi: 10.1093/jac/dkv226. Epub 2015 Aug 5. J Antimicrob Chemother. 2015. PMID: 26245639 Free PMC article.

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