Lloyd MD - Search Results

1

Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor.

Sunderland PT, Dhami A, Mahon MF, Jones LA, Tully SR, Lloyd MD, Thompson AS, Javaid H, Martin NM, Threadgill MD. Sunderland PT, et al. Among authors: lloyd md. Org Biomol Chem. 2011 Feb 7;9(3):881-91. doi: 10.1039/c0ob00665c. Epub 2010 Dec 2. Org Biomol Chem. 2011. PMID: 21127791 Free article.

2

Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome.

Lloyd MD, Boardman KD, Smith A, van den Brink DM, Wanders RJ, Threadgill MD. Lloyd MD, et al. J Enzyme Inhib Med Chem. 2007 Oct;22(5):584-90. doi: 10.1080/14756360701425360. J Enzyme Inhib Med Chem. 2007. PMID: 18035827

3

Alpha-methylacyl-CoA racemase--an 'obscure' metabolic enzyme takes centre stage.

Lloyd MD, Darley DJ, Wierzbicki AS, Threadgill MD. Lloyd MD, et al. FEBS J. 2008 Mar;275(6):1089-102. doi: 10.1111/j.1742-4658.2008.06290.x. Epub 2008 Feb 12. FEBS J. 2008. PMID: 18279392 Free article. Review.

4

Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.

Lord AM, Mahon MF, Lloyd MD, Threadgill MD. Lord AM, et al. Among authors: lloyd md. J Med Chem. 2009 Feb 12;52(3):868-77. doi: 10.1021/jm8013629. J Med Chem. 2009. PMID: 19117416

5

Synthesis and use of isotope-labelled substrates for a mechanistic study on human alpha-methylacyl-CoA racemase 1A (AMACR; P504S).

Darley DJ, Butler DS, Prideaux SJ, Thornton TW, Wilson AD, Woodman TJ, Threadgill MD, Lloyd MD. Darley DJ, et al. Among authors: lloyd md. Org Biomol Chem. 2009 Feb 7;7(3):543-52. doi: 10.1039/b815396e. Epub 2008 Nov 28. Org Biomol Chem. 2009. PMID: 19156321

6

Unexpected stereoselective exchange of straight-chain fatty acyl-CoA alpha-protons by human alpha-methylacyl-CoA racemase 1A (P504S).

Sattar FA, Darley DJ, Politano F, Woodman TJ, Threadgill MD, Lloyd MD. Sattar FA, et al. Among authors: lloyd md. Chem Commun (Camb). 2010 May 21;46(19):3348-50. doi: 10.1039/c002509g. Epub 2010 Mar 30. Chem Commun (Camb). 2010. PMID: 20442897

7

5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).

Sunderland PT, Woon EC, Dhami A, Bergin AB, Mahon MF, Wood PJ, Jones LA, Tully SR, Lloyd MD, Thompson AS, Javaid H, Martin NM, Threadgill MD. Sunderland PT, et al. Among authors: lloyd md. J Med Chem. 2011 Apr 14;54(7):2049-59. doi: 10.1021/jm1010918. Epub 2011 Mar 18. J Med Chem. 2011. PMID: 21417348 Free article.

8

Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1.

Holbourn KP, Lloyd MD, Thompson AS, Threadgill MD, Acharya KR. Holbourn KP, et al. Among authors: lloyd md. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):461-3. doi: 10.1107/S1744309111003277. Epub 2011 Mar 25. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21505241 Free PMC article.

9

Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)--a potential mechanism for the anti-cancer effects of ibuprofen.

Woodman TJ, Wood PJ, Thompson AS, Hutchings TJ, Steel GR, Jiao P, Threadgill MD, Lloyd MD. Woodman TJ, et al. Among authors: lloyd md. Chem Commun (Camb). 2011 Jul 14;47(26):7332-4. doi: 10.1039/c1cc10763a. Epub 2011 May 26. Chem Commun (Camb). 2011. PMID: 21614403

10

N3-alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides.

Nathubhai A, Patterson R, Woodman TJ, Sharp HE, Chui MT, Chung HH, Lau SW, Zheng J, Lloyd MD, Thompson AS, Threadgill MD. Nathubhai A, et al. Among authors: lloyd md. Org Biomol Chem. 2011 Sep 7;9(17):6089-99. doi: 10.1039/c1ob05430a. Epub 2011 Jul 13. Org Biomol Chem. 2011. PMID: 21750829

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