Threadgill MD - Search Results

1

Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor.

Sunderland PT, Dhami A, Mahon MF, Jones LA, Tully SR, Lloyd MD, Thompson AS, Javaid H, Martin NM, Threadgill MD. Sunderland PT, et al. Among authors: threadgill md. Org Biomol Chem. 2011 Feb 7;9(3):881-91. doi: 10.1039/c0ob00665c. Epub 2010 Dec 2. Org Biomol Chem. 2011. PMID: 21127791 Free article.

2

Synthesis of meso-substituted porphyrins carrying carboranes and oligo(ethylene glycol) units for potential applications in boron neutron capture therapy.

Frixa C, Mahon MF, Thompson AS, Threadgill MD. Frixa C, et al. Among authors: threadgill md. Org Biomol Chem. 2003 Jan 21;1(2):306-17. doi: 10.1039/b209534c. Org Biomol Chem. 2003. PMID: 12929426

3

Formation of 3-aryl-5-nitroisocoumarins from 5-nitroisocoumarins and aromatic acyl chlorides under Friedel-Crafts conditions.

Sunderland PT, Thompson AS, Threadgill MD. Sunderland PT, et al. Among authors: threadgill md. J Org Chem. 2007 Sep 14;72(19):7409-12. doi: 10.1021/jo0711236. Epub 2007 Aug 23. J Org Chem. 2007. PMID: 17715975

4

Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhibitor.

Lord AM, Mahon MF, Lloyd MD, Threadgill MD. Lord AM, et al. Among authors: threadgill md. J Med Chem. 2009 Feb 12;52(3):868-77. doi: 10.1021/jm8013629. J Med Chem. 2009. PMID: 19117416

5

5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).

Sunderland PT, Woon EC, Dhami A, Bergin AB, Mahon MF, Wood PJ, Jones LA, Tully SR, Lloyd MD, Thompson AS, Javaid H, Martin NM, Threadgill MD. Sunderland PT, et al. Among authors: threadgill md. J Med Chem. 2011 Apr 14;54(7):2049-59. doi: 10.1021/jm1010918. Epub 2011 Mar 18. J Med Chem. 2011. PMID: 21417348 Free article.

6

N3-alkylation during formation of quinazolin-4-ones from condensation of anthranilamides and orthoamides.

Nathubhai A, Patterson R, Woodman TJ, Sharp HE, Chui MT, Chung HH, Lau SW, Zheng J, Lloyd MD, Thompson AS, Threadgill MD. Nathubhai A, et al. Among authors: threadgill md. Org Biomol Chem. 2011 Sep 7;9(17):6089-99. doi: 10.1039/c1ob05430a. Epub 2011 Jul 13. Org Biomol Chem. 2011. PMID: 21750829

7

One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.

Woon EC, Sunderland PT, Paine HA, Lloyd MD, Thompson AS, Threadgill MD. Woon EC, et al. Among authors: threadgill md. Bioorg Med Chem. 2013 Sep 1;21(17):5218-27. doi: 10.1016/j.bmc.2013.06.031. Epub 2013 Jun 22. Bioorg Med Chem. 2013. PMID: 23849206

8

Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.

Paine HA, Nathubhai A, Woon EC, Sunderland PT, Wood PJ, Mahon MF, Lloyd MD, Thompson AS, Haikarainen T, Narwal M, Lehtiö L, Threadgill MD. Paine HA, et al. Among authors: threadgill md. Bioorg Med Chem. 2015 Sep 1;23(17):5891-908. doi: 10.1016/j.bmc.2015.06.061. Epub 2015 Jul 2. Bioorg Med Chem. 2015. PMID: 26189030

9

Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases.

Nathubhai A, Haikarainen T, Hayward PC, Muñoz-Descalzo S, Thompson AS, Lloyd MD, Lehtiö L, Threadgill MD. Nathubhai A, et al. Among authors: threadgill md. Eur J Med Chem. 2016 Aug 8;118:316-27. doi: 10.1016/j.ejmech.2016.04.041. Epub 2016 Apr 20. Eur J Med Chem. 2016. PMID: 27163581

10

Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis.

El-Hamamsy MH, Smith AW, Thompson AS, Threadgill MD. El-Hamamsy MH, et al. Among authors: threadgill md. Bioorg Med Chem. 2007 Jul 1;15(13):4552-76. doi: 10.1016/j.bmc.2007.04.011. Epub 2007 Apr 10. Bioorg Med Chem. 2007. PMID: 17451962 Free article.

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