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Hammerhead ribozymes with cleavage site specificity for NUH and NCH display significant anti-hepatitis C viral effect in vitro and in recombinant HepG2 and CCL13 cells.
Gonzalez-Carmona MA, Schüssler S, Serwe M, Alt M, Ludwig J, Sproat BS, Steigerwald R, Hoffmann P, Quasdorff M, Schildgen O, Caselmann WH. Gonzalez-Carmona MA, et al. Among authors: serwe m. J Hepatol. 2006 Jun;44(6):1017-25. doi: 10.1016/j.jhep.2005.10.022. Epub 2005 Dec 5. J Hepatol. 2006. PMID: 16469406
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