Schultes CM - Search Results

1

ELR510444, a novel microtubule disruptor with multiple mechanisms of action.

Risinger AL, Westbrook CD, Encinas A, Mülbaier M, Schultes CM, Wawro S, Lewis JD, Janssen B, Giles FJ, Mooberry SL. Risinger AL, et al. Among authors: schultes cm. J Pharmacol Exp Ther. 2011 Mar;336(3):652-60. doi: 10.1124/jpet.110.175331. Epub 2010 Dec 9. J Pharmacol Exp Ther. 2011. PMID: 21148249 Free PMC article.

2

ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma.

Carew JS, Esquivel JA 2nd, Espitia CM, Schultes CM, Mülbaier M, Lewis JD, Janssen B, Giles FJ, Nawrocki ST. Carew JS, et al. Among authors: schultes cm. PLoS One. 2012;7(1):e31120. doi: 10.1371/journal.pone.0031120. Epub 2012 Jan 25. PLoS One. 2012. PMID: 22295124 Free PMC article.

3

Toluidinesulfonamide hypoxia-induced factor 1 inhibitors: alleviating drug-drug interactions through use of PubChem data and comparative molecular field analysis guided synthesis.

Wendt B, Mulbaier M, Wawro S, Schultes C, Alonso J, Janssen B, Lewis J. Wendt B, et al. J Med Chem. 2011 Jun 9;54(11):3982-6. doi: 10.1021/jm200272h. Epub 2011 May 16. J Med Chem. 2011. PMID: 21574568

4

Mechanism of acridine-based telomerase inhibition and telomere shortening.

Gunaratnam M, Greciano O, Martins C, Reszka AP, Schultes CM, Morjani H, Riou JF, Neidle S. Gunaratnam M, et al. Among authors: schultes cm. Biochem Pharmacol. 2007 Sep 1;74(5):679-89. doi: 10.1016/j.bcp.2007.06.011. Epub 2007 Jun 16. Biochem Pharmacol. 2007. PMID: 17631279

5

Telomerase inhibitors in cancer therapy: current status and future directions.

Incles CM, Schultes CM, Neidle S. Incles CM, et al. Among authors: schultes cm. Curr Opin Investig Drugs. 2003 Jun;4(6):675-85. Curr Opin Investig Drugs. 2003. PMID: 12901225 Review.

6

Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor.

Incles CM, Schultes CM, Kelland LR, Neidle S. Incles CM, et al. Among authors: schultes cm. Mol Pharmacol. 2003 Nov;64(5):1101-8. doi: 10.1124/mol.64.5.1101. Mol Pharmacol. 2003. PMID: 14573759

7

Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.

Moore MJ, Schultes CM, Cuesta J, Cuenca F, Gunaratnam M, Tanious FA, Wilson WD, Neidle S. Moore MJ, et al. Among authors: schultes cm. J Med Chem. 2006 Jan 26;49(2):582-99. doi: 10.1021/jm050555a. J Med Chem. 2006. PMID: 16420044

8

Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors.

Schultes CM, Guyen B, Cuesta J, Neidle S. Schultes CM, et al. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4347-51. doi: 10.1016/j.bmcl.2004.05.090. Bioorg Med Chem Lett. 2004. PMID: 15261300

9

A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells.

Incles CM, Schultes CM, Kempski H, Koehler H, Kelland LR, Neidle S. Incles CM, et al. Among authors: schultes cm. Mol Cancer Ther. 2004 Oct;3(10):1201-6. Mol Cancer Ther. 2004. PMID: 15486186

10

The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

Burger AM, Dai F, Schultes CM, Reszka AP, Moore MJ, Double JA, Neidle S. Burger AM, et al. Among authors: schultes cm. Cancer Res. 2005 Feb 15;65(4):1489-96. doi: 10.1158/0008-5472.CAN-04-2910. Cancer Res. 2005. PMID: 15735037

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