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The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss.
Pratap J, Akech J, Wixted JJ, Szabo G, Hussain S, McGee-Lawrence ME, Li X, Bedard K, Dhillon RJ, van Wijnen AJ, Stein JL, Stein GS, Westendorf JJ, Lian JB. Pratap J, et al. Mol Cancer Ther. 2010 Dec;9(12):3210-20. doi: 10.1158/1535-7163.MCT-10-0572. Mol Cancer Ther. 2010. PMID: 21159607 Free PMC article.
Reply to vorinostat induced bone loss in mice.
McGee-Lawrence ME, Westendorf JJ. McGee-Lawrence ME, et al. Bone. 2013 Dec;57(2):531-2. doi: 10.1016/j.bone.2013.08.019. Epub 2013 Aug 23. Bone. 2013. PMID: 23973558 No abstract available.
Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2.
Dudakovic A, Camilleri ET, Xu F, Riester SM, McGee-Lawrence ME, Bradley EW, Paradise CR, Lewallen EA, Thaler R, Deyle DR, Larson AN, Lewallen DG, Dietz AB, Stein GS, Montecino MA, Westendorf JJ, van Wijnen AJ. Dudakovic A, et al. J Biol Chem. 2015 Nov 13;290(46):27604-17. doi: 10.1074/jbc.M115.672345. Epub 2015 Sep 30. J Biol Chem. 2015. PMID: 26424790 Free PMC article.
97 results