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Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective.
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F. Caraci F, et al. Among authors: copani a. Mol Pharmacol. 2011 Mar;79(3):618-26. doi: 10.1124/mol.110.067488. Epub 2010 Dec 15. Mol Pharmacol. 2011. PMID: 21159998
Metabotropic glutamate receptors and neuronal toxicity.
Aleppo G, Pisani A, Copani A, Bruno V, Aronica E, D'Agata V, Canonico PL, Nicoletti F. Aleppo G, et al. Among authors: copani a. Adv Exp Med Biol. 1992;318:137-45. doi: 10.1007/978-1-4615-3426-6_12. Adv Exp Med Biol. 1992. PMID: 1322025 No abstract available.
128 results