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Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective.
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F. Caraci F, et al. Among authors: traficante a. Mol Pharmacol. 2011 Mar;79(3):618-26. doi: 10.1124/mol.110.067488. Epub 2010 Dec 15. Mol Pharmacol. 2011. PMID: 21159998
Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.
Molinaro G, Traficante A, Riozzi B, Di Menna L, Curto M, Pallottino S, Nicoletti F, Bruno V, Battaglia G. Molinaro G, et al. Among authors: traficante a. Mol Pharmacol. 2009 Aug;76(2):379-87. doi: 10.1124/mol.109.056580. Epub 2009 May 13. Mol Pharmacol. 2009. PMID: 19439499
Type-3 metabotropic glutamate receptors regulate chemoresistance in glioma stem cells, and their levels are inversely related to survival in patients with malignant gliomas.
Ciceroni C, Bonelli M, Mastrantoni E, Niccolini C, Laurenza M, Larocca LM, Pallini R, Traficante A, Spinsanti P, Ricci-Vitiani L, Arcella A, De Maria R, Nicoletti F, Battaglia G, Melchiorri D. Ciceroni C, et al. Among authors: traficante a. Cell Death Differ. 2013 Mar;20(3):396-407. doi: 10.1038/cdd.2012.150. Epub 2012 Nov 23. Cell Death Differ. 2013. PMID: 23175182 Free PMC article.
Gender differences in Parkinson's disease: focus on plasma α-synuclein.
Caranci G, Piscopo P, Rivabene R, Traficante A, Riozzi B, Castellano AE, Ruggieri S, Vanacore N, Confaloni A. Caranci G, et al. Among authors: traficante a. J Neural Transm (Vienna). 2013 Aug;120(8):1209-15. doi: 10.1007/s00702-013-0972-6. Epub 2013 Jan 18. J Neural Transm (Vienna). 2013. PMID: 23328951 Review.
5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice.
Busceti CL, Di Pietro P, Riozzi B, Traficante A, Biagioni F, Nisticò R, Fornai F, Battaglia G, Nicoletti F, Bruno V. Busceti CL, et al. Among authors: traficante a. Pharmacol Res. 2015 Sep;99:258-68. doi: 10.1016/j.phrs.2015.06.017. Epub 2015 Jul 2. Pharmacol Res. 2015. PMID: 26145279
65 results