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Page 1
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus.
Cherkasov A, Hsing M, Zoraghi R, Foster LJ, See RH, Stoynov N, Jiang J, Kaur S, Lian T, Jackson L, Gong H, Swayze R, Amandoron E, Hormozdiari F, Dao P, Sahinalp C, Santos-Filho O, Axerio-Cilies P, Byler K, McMaster WR, Brunham RC, Finlay BB, Reiner NE. Cherkasov A, et al. Among authors: gong h. J Proteome Res. 2011 Mar 4;10(3):1139-50. doi: 10.1021/pr100918u. Epub 2011 Jan 28. J Proteome Res. 2011. PMID: 21166474
Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target.
Zoraghi R, See RH, Axerio-Cilies P, Kumar NS, Gong H, Moreau A, Hsing M, Kaur S, Swayze RD, Worrall L, Amandoron E, Lian T, Jackson L, Jiang J, Thorson L, Labriere C, Foster L, Brunham RC, McMaster WR, Finlay BB, Strynadka NC, Cherkasov A, Young RN, Reiner NE. Zoraghi R, et al. Among authors: gong h. Antimicrob Agents Chemother. 2011 May;55(5):2042-53. doi: 10.1128/AAC.01250-10. Epub 2011 Feb 28. Antimicrob Agents Chemother. 2011. PMID: 21357306 Free PMC article.
Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.
Zoraghi R, Worrall L, See RH, Strangman W, Popplewell WL, Gong H, Samaai T, Swayze RD, Kaur S, Vuckovic M, Finlay BB, Brunham RC, McMaster WR, Davies-Coleman MT, Strynadka NC, Andersen RJ, Reiner NE. Zoraghi R, et al. Among authors: gong h. J Biol Chem. 2011 Dec 30;286(52):44716-25. doi: 10.1074/jbc.M111.289033. Epub 2011 Oct 26. J Biol Chem. 2011. PMID: 22030393 Free PMC article.
We have recently identified pyruvate kinase (PK) as a potential novel drug target based upon it being an essential hub in the MRSA interactome (Cherkasov, A., Hsing, M., Zoraghi, R., Foster, L. J., See, R. H., Stoynov, N., Jiang, J., Kaur, S., Lian, T., Jackson, L., Gon …
We have recently identified pyruvate kinase (PK) as a potential novel drug target based upon it being an essential hub in the MRSA interacto …
Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase.
Axerio-Cilies P, See RH, Zoraghi R, Worral L, Lian T, Stoynov N, Jiang J, Kaur S, Jackson L, Gong H, Swayze R, Amandoron E, Kumar NS, Moreau A, Hsing M, Strynadka NC, McMaster WR, Finlay BB, Foster LJ, Young RN, Reiner NE, Cherkasov A. Axerio-Cilies P, et al. Among authors: gong h. ACS Chem Biol. 2012 Feb 17;7(2):350-9. doi: 10.1021/cb2003576. Epub 2011 Nov 21. ACS Chem Biol. 2012. PMID: 22066782
Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections.
Kumar NS, Dullaghan EM, Finlay BB, Gong H, Reiner NE, Jon Paul Selvam J, Thorson LM, Campbell S, Vitko N, Richardson AR, Zoraghi R, Young RN. Kumar NS, et al. Among authors: gong h. Bioorg Med Chem. 2014 Mar 1;22(5):1708-25. doi: 10.1016/j.bmc.2014.01.020. Epub 2014 Jan 24. Bioorg Med Chem. 2014. PMID: 24508307 Free PMC article.
Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents.
Kumar NS, Amandoron EA, Cherkasov A, Finlay BB, Gong H, Jackson L, Kaur S, Lian T, Moreau A, Labrière C, Reiner NE, See RH, Strynadka NC, Thorson L, Wong EW, Worrall L, Zoraghi R, Young RN. Kumar NS, et al. Among authors: gong h. Bioorg Med Chem. 2012 Dec 15;20(24):7069-82. doi: 10.1016/j.bmc.2012.10.002. Epub 2012 Oct 17. Bioorg Med Chem. 2012. PMID: 23141418
Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase.
Chan BC, Ip M, Lau CB, Lui SL, Jolivalt C, Ganem-Elbaz C, Litaudon M, Reiner NE, Gong H, See RH, Fung KP, Leung PC. Chan BC, et al. Among authors: gong h. J Ethnopharmacol. 2011 Sep 1;137(1):767-73. doi: 10.1016/j.jep.2011.06.039. Epub 2011 Jul 1. J Ethnopharmacol. 2011. PMID: 21782012
5,148 results