Kimura H - Search Results

1

BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression.

Kimura H, Sato Y, Tajima Y, Suzuki H, Yukitake H, Imaeda T, Kajino M, Oki H, Takizawa M, Tanida S. Kimura H, et al. Chem Biol. 2010 Dec 22;17(12):1282-94. doi: 10.1016/j.chembiol.2010.10.011. Chem Biol. 2010. PMID: 21168764

2

The chondroprotective agent ITZ-1 inhibits interleukin-1beta-induced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death.

Kimura H, Yukitake H, Suzuki H, Tajima Y, Gomaibashi K, Morimoto S, Funabashi Y, Yamada K, Takizawa M. Kimura H, et al. J Pharmacol Sci. 2009 Jun;110(2):201-11. doi: 10.1254/jphs.09076fp. J Pharmacol Sci. 2009. PMID: 19542681 Free article.

3

ITZ-1, a client-selective Hsp90 inhibitor, efficiently induces heat shock factor 1 activation.

Kimura H, Yukitake H, Tajima Y, Suzuki H, Chikatsu T, Morimoto S, Funabashi Y, Omae H, Ito T, Yoneda Y, Takizawa M. Kimura H, et al. Chem Biol. 2010 Jan 29;17(1):18-27. doi: 10.1016/j.chembiol.2009.12.012. Chem Biol. 2010. PMID: 20142037

4

BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats.

Yukitake H, Kimura H, Suzuki H, Tajima Y, Sato Y, Imaeda T, Kajino M, Takizawa M. Yukitake H, et al. Among authors: kimura h. PLoS One. 2011;6(8):e23256. doi: 10.1371/journal.pone.0023256. Epub 2011 Aug 10. PLoS One. 2011. PMID: 21853095 Free PMC article.

5

BTZO-2, an antioxidant response element-activator, provides protection against lethal endotoxic shock in mice.

Yukitake H, Kimura H, Tajima Y, Sato Y, Suzuki H, Kajino M, Tanida S, Takizawa M. Yukitake H, et al. Among authors: kimura h. Eur J Pharmacol. 2013 Jan 30;700(1-3):80-5. doi: 10.1016/j.ejphar.2012.12.014. Epub 2012 Dec 28. Eur J Pharmacol. 2013. PMID: 23276667

6

Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.

Kunitomo J, Yoshikawa M, Fushimi M, Kawada A, Quinn JF, Oki H, Kokubo H, Kondo M, Nakashima K, Kamiguchi N, Suzuki K, Kimura H, Taniguchi T. Kunitomo J, et al. Among authors: kimura h. J Med Chem. 2014 Nov 26;57(22):9627-43. doi: 10.1021/jm5013648. Epub 2014 Nov 10. J Med Chem. 2014. PMID: 25384088

7

Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor.

Yoshikawa M, Kamisaki H, Kunitomo J, Oki H, Kokubo H, Suzuki A, Ikemoto T, Nakashima K, Kamiguchi N, Harada A, Kimura H, Taniguchi T. Yoshikawa M, et al. Among authors: kimura h. Bioorg Med Chem. 2015 Nov 15;23(22):7138-49. doi: 10.1016/j.bmc.2015.10.002. Epub 2015 Oct 9. Bioorg Med Chem. 2015. PMID: 26494583

8

TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms.

Suzuki K, Harada A, Suzuki H, Miyamoto M, Kimura H. Suzuki K, et al. Among authors: kimura h. Neuropsychopharmacology. 2016 Aug;41(9):2252-62. doi: 10.1038/npp.2016.20. Epub 2016 Feb 5. Neuropsychopharmacology. 2016. PMID: 26849714 Free PMC article.

9

Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System.

Yukitake H, Takizawa M, Kimura H. Yukitake H, et al. Among authors: kimura h. Oxid Med Cell Longev. 2017;2017:8584930. doi: 10.1155/2017/8584930. Epub 2017 Jan 16. Oxid Med Cell Longev. 2017. PMID: 28191280 Free PMC article. Review.

10

HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production.

Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. Kunugi A, et al. Among authors: kimura h. J Pharmacol Exp Ther. 2018 Mar;364(3):377-389. doi: 10.1124/jpet.117.245050. Epub 2018 Jan 3. J Pharmacol Exp Ther. 2018. PMID: 29298820

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