Hellwig CT - Search Results

1

The molecular machinery regulating apoptosis signal transduction and its implication in human physiology and pathophysiologies.

Hellwig CT, Passante E, Rehm M. Hellwig CT, et al. Curr Mol Med. 2011 Feb;11(1):31-47. doi: 10.2174/156652411794474400. Curr Mol Med. 2011. PMID: 21189119 Review.

2

Dynamics of outer mitochondrial membrane permeabilization during apoptosis.

Rehm M, Huber HJ, Hellwig CT, Anguissola S, Dussmann H, Prehn JH. Rehm M, et al. Among authors: hellwig ct. Cell Death Differ. 2009 Apr;16(4):613-23. doi: 10.1038/cdd.2008.187. Epub 2009 Jan 9. Cell Death Differ. 2009. PMID: 19136937

3

Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells.

Passante E, Würstle ML, Hellwig CT, Leverkus M, Rehm M. Passante E, et al. Among authors: hellwig ct. Cell Death Differ. 2013 Nov;20(11):1521-31. doi: 10.1038/cdd.2013.106. Epub 2013 Aug 9. Cell Death Differ. 2013. PMID: 23933815 Free PMC article.

4

Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor necrosis factor-related apoptosis inducing ligand (TRAIL) signaling.

Laussmann MA, Passante E, Hellwig CT, Tomiczek B, Flanagan L, Prehn JH, Huber HJ, Rehm M. Laussmann MA, et al. Among authors: hellwig ct. J Biol Chem. 2012 Apr 27;287(18):14402-11. doi: 10.1074/jbc.M111.304378. Epub 2012 Mar 9. J Biol Chem. 2012. PMID: 22408249 Free PMC article.

5

Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation.

Hellwig CT, Kohler BF, Lehtivarjo AK, Dussmann H, Courtney MJ, Prehn JH, Rehm M. Hellwig CT, et al. J Biol Chem. 2008 Aug 1;283(31):21676-85. doi: 10.1074/jbc.M802889200. Epub 2008 Jun 3. J Biol Chem. 2008. PMID: 18522940 Free article.

6

Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711.

Crawford N, Salvucci M, Hellwig CT, Lincoln FA, Mooney RE, O'Connor CL, Prehn JH, Longley DB, Rehm M. Crawford N, et al. Among authors: hellwig ct. Cell Death Differ. 2018 Nov;25(11):1952-1966. doi: 10.1038/s41418-018-0082-y. Epub 2018 Mar 2. Cell Death Differ. 2018. PMID: 29500433 Free PMC article.

7

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.

Hellwig CT, Ludwig-Galezowska AH, Concannon CG, Litchfield DW, Prehn JH, Rehm M. Hellwig CT, et al. J Cell Sci. 2010 May 1;123(Pt 9):1401-6. doi: 10.1242/jcs.061143. Epub 2010 Mar 31. J Cell Sci. 2010. PMID: 20356928 Free article.

8

TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies.

Hellwig CT, Rehm M. Hellwig CT, et al. Mol Cancer Ther. 2012 Jan;11(1):3-13. doi: 10.1158/1535-7163.MCT-11-0434. Mol Cancer Ther. 2012. PMID: 22234808 Review.

9

Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol.

Hellwig CT, Delgado ME, Skoko J, Dyck L, Hanna C, Wentges A, Langlais C, Hagenlocher C, Mack A, Dinsdale D, Cain K, MacFarlane M, Rehm M. Hellwig CT, et al. Cell Death Differ. 2022 Jan;29(1):147-155. doi: 10.1038/s41418-021-00843-7. Epub 2021 Aug 5. Cell Death Differ. 2022. PMID: 34354257 Free PMC article.

10

Examining the In Vitro Efficacy of the IAP Antagonist Birinapant as a Single Agent or in Combination With Dacarbazine to Induce Melanoma Cell Death.

Vetma V, Rožanc J, Charles EM, Hellwig CT, Alexopoulos LG, Rehm M. Vetma V, et al. Among authors: hellwig ct. Oncol Res. 2017 Nov 2;25(9):1489-1494. doi: 10.3727/096504017X14897145996933. Epub 2017 Mar 23. Oncol Res. 2017. PMID: 28337955 Free PMC article.

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