Kelly JW - Search Results

1

Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion.

Bourgault S, Solomon JP, Reixach N, Kelly JW. Bourgault S, et al. Among authors: kelly jw. Biochemistry. 2011 Feb 15;50(6):1001-15. doi: 10.1021/bi101822y. Epub 2011 Jan 24. Biochemistry. 2011. PMID: 21194234 Free PMC article.

2

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro.

Colon W, Kelly JW. Colon W, et al. Among authors: kelly jw. Biochemistry. 1992 Sep 15;31(36):8654-60. doi: 10.1021/bi00151a036. Biochemistry. 1992. PMID: 1390650

3

Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.

McCutchen SL, Lai Z, Miroy GJ, Kelly JW, Colón W. McCutchen SL, et al. Among authors: kelly jw. Biochemistry. 1995 Oct 17;34(41):13527-36. doi: 10.1021/bi00041a032. Biochemistry. 1995. PMID: 7577941

4

Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity.

McCutchen SL, Colon W, Kelly JW. McCutchen SL, et al. Among authors: kelly jw. Biochemistry. 1993 Nov 16;32(45):12119-27. doi: 10.1021/bi00096a024. Biochemistry. 1993. PMID: 8218290

5

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid.

Lai Z, Colón W, Kelly JW. Lai Z, et al. Among authors: kelly jw. Biochemistry. 1996 May 21;35(20):6470-82. doi: 10.1021/bi952501g. Biochemistry. 1996. PMID: 8639594

6

Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers.

Lai Z, McCulloch J, Lashuel HA, Kelly JW. Lai Z, et al. Among authors: kelly jw. Biochemistry. 1997 Aug 19;36(33):10230-9. doi: 10.1021/bi963195p. Biochemistry. 1997. PMID: 9254621

7

Transthyretin quaternary and tertiary structural changes facilitate misassembly into amyloid.

Kelly JW, Colon W, Lai Z, Lashuel HA, McCulloch J, McCutchen SL, Miroy GJ, Peterson SA. Kelly JW, et al. Adv Protein Chem. 1997;50:161-81. doi: 10.1016/s0065-3233(08)60321-6. Adv Protein Chem. 1997. PMID: 9338081 Review.

8

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.

Peterson SA, Klabunde T, Lashuel HA, Purkey H, Sacchettini JC, Kelly JW. Peterson SA, et al. Among authors: kelly jw. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):12956-60. doi: 10.1073/pnas.95.22.12956. Proc Natl Acad Sci U S A. 1998. PMID: 9789022 Free PMC article.

9

Comparative characterization of a wild type and transmembrane domain-deleted fatty acid amide hydrolase: identification of the transmembrane domain as a site for oligomerization.

Patricelli MP, Lashuel HA, Giang DK, Kelly JW, Cravatt BF. Patricelli MP, et al. Among authors: kelly jw. Biochemistry. 1998 Oct 27;37(43):15177-87. doi: 10.1021/bi981733n. Biochemistry. 1998. PMID: 9790682

10

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation.

Lashuel HA, Lai Z, Kelly JW. Lashuel HA, et al. Among authors: kelly jw. Biochemistry. 1998 Dec 22;37(51):17851-64. doi: 10.1021/bi981876+. Biochemistry. 1998. PMID: 9922152

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