Reixach N - Search Results

1

Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion.

Bourgault S, Solomon JP, Reixach N, Kelly JW. Bourgault S, et al. Among authors: reixach n. Biochemistry. 2011 Feb 15;50(6):1001-15. doi: 10.1021/bi101822y. Epub 2011 Jan 24. Biochemistry. 2011. PMID: 21194234 Free PMC article.

2

Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture.

Reixach N, Deechongkit S, Jiang X, Kelly JW, Buxbaum JN. Reixach N, et al. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2817-22. doi: 10.1073/pnas.0400062101. Epub 2004 Feb 23. Proc Natl Acad Sci U S A. 2004. PMID: 14981241 Free PMC article.

3

Cell based screening of inhibitors of transthyretin aggregation.

Reixach N, Adamski-Werner SL, Kelly JW, Koziol J, Buxbaum JN. Reixach N, et al. Biochem Biophys Res Commun. 2006 Sep 29;348(3):889-97. doi: 10.1016/j.bbrc.2006.07.109. Epub 2006 Jul 31. Biochem Biophys Res Commun. 2006. PMID: 16904635

4

Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins.

Reixach N, Foss TR, Santelli E, Pascual J, Kelly JW, Buxbaum JN. Reixach N, et al. J Biol Chem. 2008 Jan 25;283(4):2098-107. doi: 10.1074/jbc.M708028200. Epub 2007 Nov 15. J Biol Chem. 2008. PMID: 18006495 Free article.

5

A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.

Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW. Choi S, et al. Among authors: reixach n. J Am Chem Soc. 2010 Feb 3;132(4):1359-70. doi: 10.1021/ja908562q. J Am Chem Soc. 2010. PMID: 20043671 Free PMC article.

6

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.

Choi S, Connelly S, Reixach N, Wilson IA, Kelly JW. Choi S, et al. Among authors: reixach n. Nat Chem Biol. 2010 Feb;6(2):133-9. doi: 10.1038/nchembio.281. Nat Chem Biol. 2010. PMID: 20081815 Free PMC article.

7

Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs.

Bourgault S, Choi S, Buxbaum JN, Kelly JW, Price JL, Reixach N. Bourgault S, et al. Among authors: reixach n. Biochem Biophys Res Commun. 2011 Jul 15;410(4):707-13. doi: 10.1016/j.bbrc.2011.04.133. Epub 2011 May 4. Biochem Biophys Res Commun. 2011. PMID: 21557933 Free PMC article.

8

Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.

Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA. Alhamadsheh MM, et al. Among authors: reixach n. Sci Transl Med. 2011 Aug 24;3(97):97ra81. doi: 10.1126/scitranslmed.3002473. Sci Transl Med. 2011. PMID: 21865539 Free PMC article.

9

Age-related oxidative modifications of transthyretin modulate its amyloidogenicity.

Zhao L, Buxbaum JN, Reixach N. Zhao L, et al. Among authors: reixach n. Biochemistry. 2013 Mar 19;52(11):1913-26. doi: 10.1021/bi301313b. Epub 2013 Mar 4. Biochemistry. 2013. PMID: 23414091 Free PMC article.

10

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.

Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, Graef IA, Alhamadsheh MM. Penchala SC, et al. Among authors: reixach n. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. doi: 10.1073/pnas.1300761110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716704 Free PMC article.

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