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Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.
Zeng Z, Samudio IJ, Zhang W, Estrov Z, Pelicano H, Harris D, Frolova O, Hail N Jr, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M, Konopleva M. Zeng Z, et al. Among authors: zhang w. Cancer Res. 2006 Apr 1;66(7):3737-46. doi: 10.1158/0008-5472.CAN-05-1278. Cancer Res. 2006. PMID: 16585200
Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia.
Zhang W, Konopleva M, Shi YX, McQueen T, Harris D, Ling X, Estrov Z, Quintás-Cardama A, Small D, Cortes J, Andreeff M. Zhang W, et al. J Natl Cancer Inst. 2008 Feb 6;100(3):184-98. doi: 10.1093/jnci/djm328. Epub 2008 Jan 29. J Natl Cancer Inst. 2008. PMID: 18230792 Clinical Trial.
Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.
Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. Zhang W, et al. Cancer Res. 2010 Mar 15;70(6):2424-34. doi: 10.1158/0008-5472.CAN-09-0878. Epub 2010 Mar 9. Cancer Res. 2010. PMID: 20215498 Free PMC article.
Phase I study of sorafenib in patients with refractory or relapsed acute leukemias.
Borthakur G, Kantarjian H, Ravandi F, Zhang W, Konopleva M, Wright JJ, Faderl S, Verstovsek S, Mathews S, Andreeff M, Cortes JE. Borthakur G, et al. Among authors: zhang w. Haematologica. 2011 Jan;96(1):62-8. doi: 10.3324/haematol.2010.030452. Epub 2010 Oct 15. Haematologica. 2011. PMID: 20952518 Free PMC article. Clinical Trial.
89,280 results
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