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Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.
Conti P, De Amici M, Grazioso G, Roda G, Pinto A, Hansen KB, Nielsen B, Madsen U, Bräuner-Osborne H, Egebjerg J, Vestri V, Pellegrini-Giampietro DE, Sibille P, Acher FC, De Micheli C. Conti P, et al. Among authors: pinto a. J Med Chem. 2005 Oct 6;48(20):6315-25. doi: 10.1021/jm0504499. J Med Chem. 2005. PMID: 16190758
Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake.
Colleoni S, Jensen AA, Landucci E, Fumagalli E, Conti P, Pinto A, De Amici M, Pellegrini-Giampietro DE, De Micheli C, Mennini T, Gobbi M. Colleoni S, et al. Among authors: pinto a. J Pharmacol Exp Ther. 2008 Aug;326(2):646-56. doi: 10.1124/jpet.107.135251. Epub 2008 May 1. J Pharmacol Exp Ther. 2008. PMID: 18451317
Design and synthesis of novel isoxazole-based HDAC inhibitors.
Conti P, Tamborini L, Pinto A, Sola L, Ettari R, Mercurio C, De Micheli C. Conti P, et al. Among authors: pinto a. Eur J Med Chem. 2010 Sep;45(9):4331-8. doi: 10.1016/j.ejmech.2010.06.035. Epub 2010 Jun 30. Eur J Med Chem. 2010. PMID: 20637529
Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: design, synthesis, and pharmacological characterization.
Conti P, Pinto A, Tamborini L, Madsen U, Nielsen B, Bräuner-Osborne H, Hansen KB, Landucci E, Pellegrini-Giampietro DE, De Sarro G, Donato Di Paola E, De Micheli C. Conti P, et al. Among authors: pinto a. ChemMedChem. 2010 Sep 3;5(9):1465-75. doi: 10.1002/cmdc.201000184. ChemMedChem. 2010. PMID: 20665761
4,645 results