Ulven T - Search Results

1

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

Schmidt J, Smith NJ, Christiansen E, Tikhonova IG, Grundmann M, Hudson BD, Ward RJ, Drewke C, Milligan G, Kostenis E, Ulven T. Schmidt J, et al. Among authors: ulven t. J Biol Chem. 2011 Mar 25;286(12):10628-40. doi: 10.1074/jbc.M110.210872. Epub 2011 Jan 10. J Biol Chem. 2011. PMID: 21220428 Free PMC article.

2

Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization.

Kjær VMS, Daugvilaite V, Stepniewski TM, Madsen CM, Jørgensen AS, Bhuskute KR, Inoue A, Ulven T, Benned-Jensen T, Hjorth SA, Hjortø GM, Moo EV, Selent J, Rosenkilde MM. Kjær VMS, et al. Among authors: ulven t. Sci Signal. 2023 Apr 4;16(779):eabl4283. doi: 10.1126/scisignal.abl4283. Epub 2023 Apr 4. Sci Signal. 2023. PMID: 37014928

3

Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist.

Ulven T, Kostenis E. Ulven T, et al. J Med Chem. 2005 Feb 24;48(4):897-900. doi: 10.1021/jm049036i. J Med Chem. 2005. PMID: 15715457

4

Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2.

Mathiesen JM, Ulven T, Martini L, Gerlach LO, Heinemann A, Kostenis E. Mathiesen JM, et al. Among authors: ulven t. Mol Pharmacol. 2005 Aug;68(2):393-402. doi: 10.1124/mol.104.010520. Epub 2005 May 3. Mol Pharmacol. 2005. PMID: 15870392

5

A physicogenetic method to assign ligand-binding relationships between 7TM receptors.

Frimurer TM, Ulven T, Elling CE, Gerlach LO, Kostenis E, Högberg T. Frimurer TM, et al. Among authors: ulven t. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3707-12. doi: 10.1016/j.bmcl.2005.05.102. Bioorg Med Chem Lett. 2005. PMID: 15993056

6

On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2.

Mathiesen JM, Christopoulos A, Ulven T, Royer JF, Campillo M, Heinemann A, Pardo L, Kostenis E. Mathiesen JM, et al. Among authors: ulven t. Mol Pharmacol. 2006 Apr;69(4):1441-53. doi: 10.1124/mol.105.017681. Epub 2006 Jan 17. Mol Pharmacol. 2006. PMID: 16418339

7

Emerging roles of DP and CRTH2 in allergic inflammation.

Kostenis E, Ulven T. Kostenis E, et al. Among authors: ulven t. Trends Mol Med. 2006 Apr;12(4):148-58. doi: 10.1016/j.molmed.2006.02.005. Epub 2006 Mar 20. Trends Mol Med. 2006. PMID: 16545607 Review.

8

Targeting the prostaglandin D2 receptors DP and CRTH2 for treatment of inflammation.

Ulven T, Kostenis E. Ulven T, et al. Curr Top Med Chem. 2006;6(13):1427-44. doi: 10.2174/15680266106061427. Curr Top Med Chem. 2006. PMID: 16918458 Review.

9

Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits.

Ulven T, Receveur JM, Grimstrup M, Rist Ø, Frimurer TM, Gerlach LO, Mathiesen JM, Kostenis E, Uller L, Högberg T. Ulven T, et al. J Med Chem. 2006 Nov 16;49(23):6638-41. doi: 10.1021/jm060657g. J Med Chem. 2006. PMID: 17154491

10

Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2.

Ulven T, Gallen MJ, Nielsen MC, Merten N, Schmidt C, Mohr K, Tränkle C, Kostenis E. Ulven T, et al. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5924-7. doi: 10.1016/j.bmcl.2007.07.080. Epub 2007 Aug 22. Bioorg Med Chem Lett. 2007. PMID: 17845848

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