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Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.
Singaraja RR, Van Eck M, Bissada N, Zimetti F, Collins HL, Hildebrand RB, Hayden A, Brunham LR, Kang MH, Fruchart JC, Van Berkel TJ, Parks JS, Staels B, Rothblat GH, Fiévet C, Hayden MR. Singaraja RR, et al. Among authors: hayden a, hayden mr. Circulation. 2006 Sep 19;114(12):1301-9. doi: 10.1161/CIRCULATIONAHA.106.621433. Epub 2006 Aug 28. Circulation. 2006. PMID: 16940190
Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis.
MacDonald ML, van Eck M, Hildebrand RB, Wong BW, Bissada N, Ruddle P, Kontush A, Hussein H, Pouladi MA, Chapman MJ, Fievet C, van Berkel TJ, Staels B, McManus BM, Hayden MR. MacDonald ML, et al. Among authors: hayden mr. Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):341-7. doi: 10.1161/ATVBAHA.108.181099. Epub 2008 Dec 18. Arterioscler Thromb Vasc Biol. 2009. PMID: 19095997 Free PMC article.
ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.
Trigueros-Motos L, van Capelleveen JC, Torta F, Castaño D, Zhang LH, Chai EC, Kang M, Dimova LG, Schimmel AWM, Tietjen I, Radomski C, Tan LJ, Thiam CH, Narayanaswamy P, Wu DH, Dorninger F, Yakala GK, Barhdadi A, Angeli V, Dubé MP, Berger J, Dallinga-Thie GM, Tietge UJF, Wenk MR, Hayden MR, Hovingh GK, Singaraja RR. Trigueros-Motos L, et al. Among authors: hayden mr. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2147-2155. doi: 10.1161/ATVBAHA.117.309574. Epub 2017 Sep 7. Arterioscler Thromb Vasc Biol. 2017. PMID: 28882873
Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice.
Singaraja RR, Stahmer B, Brundert M, Merkel M, Heeren J, Bissada N, Kang M, Timmins JM, Ramakrishnan R, Parks JS, Hayden MR, Rinninger F. Singaraja RR, et al. Among authors: hayden mr. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1821-7. doi: 10.1161/01.ATV.0000229219.13757.a2. Epub 2006 May 25. Arterioscler Thromb Vasc Biol. 2006. PMID: 16728652
900 results