Kelnar K - Search Results

1

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44.

Liu C, Kelnar K, Liu B, Chen X, Calhoun-Davis T, Li H, Patrawala L, Yan H, Jeter C, Honorio S, Wiggins JF, Bader AG, Fagin R, Brown D, Tang DG. Liu C, et al. Among authors: kelnar k. Nat Med. 2011 Feb;17(2):211-5. doi: 10.1038/nm.2284. Epub 2011 Jan 16. Nat Med. 2011. PMID: 21240262 Free PMC article.

2

Distinct microRNA expression profiles in prostate cancer stem/progenitor cells and tumor-suppressive functions of let-7.

Liu C, Kelnar K, Vlassov AV, Brown D, Wang J, Tang DG. Liu C, et al. Among authors: kelnar k. Cancer Res. 2012 Jul 1;72(13):3393-404. doi: 10.1158/0008-5472.CAN-11-3864. Epub 2012 Jun 19. Cancer Res. 2012. PMID: 22719071 Free PMC article.

3

Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34.

Wiggins JF, Ruffino L, Kelnar K, Omotola M, Patrawala L, Brown D, Bader AG. Wiggins JF, et al. Among authors: kelnar k. Cancer Res. 2010 Jul 15;70(14):5923-30. doi: 10.1158/0008-5472.CAN-10-0655. Epub 2010 Jun 22. Cancer Res. 2010. PMID: 20570894 Free PMC article.

4

In-depth analysis shows synergy between erlotinib and miR-34a.

Zhao J, Kelnar K, Bader AG. Zhao J, et al. Among authors: kelnar k. PLoS One. 2014 Feb 14;9(2):e89105. doi: 10.1371/journal.pone.0089105. eCollection 2014. PLoS One. 2014. PMID: 24551227 Free PMC article.

5

Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes.

Takeshita F, Patrawala L, Osaki M, Takahashi RU, Yamamoto Y, Kosaka N, Kawamata M, Kelnar K, Bader AG, Brown D, Ochiya T. Takeshita F, et al. Among authors: kelnar k. Mol Ther. 2010 Jan;18(1):181-7. doi: 10.1038/mt.2009.207. Epub 2009 Sep 8. Mol Ther. 2010. PMID: 19738602 Free PMC article.

6

Regression of murine lung tumors by the let-7 microRNA.

Trang P, Medina PP, Wiggins JF, Ruffino L, Kelnar K, Omotola M, Homer R, Brown D, Bader AG, Weidhaas JB, Slack FJ. Trang P, et al. Among authors: kelnar k. Oncogene. 2010 Mar 18;29(11):1580-7. doi: 10.1038/onc.2009.445. Epub 2009 Dec 7. Oncogene. 2010. PMID: 19966857 Free PMC article.

7

A qRT-PCR Method for Determining the Biodistribution Profile of a miR-34a Mimic.

Kelnar K, Bader AG. Kelnar K, et al. Methods Mol Biol. 2015;1317:125-33. doi: 10.1007/978-1-4939-2727-2_8. Methods Mol Biol. 2015. PMID: 26072405

8

PDL1 Regulation by p53 via miR-34.

Cortez MA, Ivan C, Valdecanas D, Wang X, Peltier HJ, Ye Y, Araujo L, Carbone DP, Shilo K, Giri DK, Kelnar K, Martin D, Komaki R, Gomez DR, Krishnan S, Calin GA, Bader AG, Welsh JW. Cortez MA, et al. Among authors: kelnar k. J Natl Cancer Inst. 2015 Nov 17;108(1):djv303. doi: 10.1093/jnci/djv303. Print 2016 Jan. J Natl Cancer Inst. 2015. PMID: 26577528 Free PMC article.

9

Synergy between next generation EGFR tyrosine kinase inhibitors and miR-34a in the inhibition of non-small cell lung cancer.

Zhao J, Guerrero A, Kelnar K, Peltier HJ, Bader AG. Zhao J, et al. Among authors: kelnar k. Lung Cancer. 2017 Jun;108:96-102. doi: 10.1016/j.lungcan.2017.02.020. Epub 2017 Mar 1. Lung Cancer. 2017. PMID: 28625657

10

Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours.

Hong DS, Kang YK, Borad M, Sachdev J, Ejadi S, Lim HY, Brenner AJ, Park K, Lee JL, Kim TY, Shin S, Becerra CR, Falchook G, Stoudemire J, Martin D, Kelnar K, Peltier H, Bonato V, Bader AG, Smith S, Kim S, O'Neill V, Beg MS. Hong DS, et al. Among authors: kelnar k. Br J Cancer. 2020 May;122(11):1630-1637. doi: 10.1038/s41416-020-0802-1. Epub 2020 Apr 2. Br J Cancer. 2020. PMID: 32238921 Free PMC article. Clinical Trial.

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