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Page 1
Epigenetics: Tools and Technologies.
Janzen WP, Wigle TJ, Jin J, Frye SV. Janzen WP, et al. Drug Discov Today Technol. 2010 Spring;7(1):e59-e65. doi: 10.1016/j.ddtec.2010.07.004. Drug Discov Today Technol. 2010. PMID: 21243036 Free PMC article.
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A, Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM, Janzen WP, Arrowsmith CH, Frye SV, Brown PJ, Simeonov A, Vedadi M, Jin J. Liu F, et al. Among authors: janzen wp. J Med Chem. 2010 Aug 12;53(15):5844-57. doi: 10.1021/jm100478y. J Med Chem. 2010. PMID: 20614940 Free PMC article.
Small-molecule ligands of methyl-lysine binding proteins.
Herold JM, Wigle TJ, Norris JL, Lam R, Korboukh VK, Gao C, Ingerman LA, Kireev DB, Senisterra G, Vedadi M, Tripathy A, Brown PJ, Arrowsmith CH, Jin J, Janzen WP, Frye SV. Herold JM, et al. Among authors: janzen wp. J Med Chem. 2011 Apr 14;54(7):2504-11. doi: 10.1021/jm200045v. Epub 2011 Mar 18. J Med Chem. 2011. PMID: 21417280 Free PMC article.
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP.
Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin J. Liu F, et al. Among authors: janzen wp. J Med Chem. 2013 Nov 14;56(21):8931-42. doi: 10.1021/jm401480r. Epub 2013 Oct 31. J Med Chem. 2013. PMID: 24102134 Free PMC article.
AMP is an adenosine A1 receptor agonist.
Rittiner JE, Korboukh I, Hull-Ryde EA, Jin J, Janzen WP, Frye SV, Zylka MJ. Rittiner JE, et al. Among authors: janzen wp. J Biol Chem. 2012 Feb 17;287(8):5301-9. doi: 10.1074/jbc.M111.291666. Epub 2012 Jan 3. J Biol Chem. 2012. PMID: 22215671 Free PMC article.
Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.
Korboukh I, Hull-Ryde EA, Rittiner JE, Randhawa AS, Coleman J, Fitzpatrick BJ, Setola V, Janzen WP, Frye SV, Zylka MJ, Jin J. Korboukh I, et al. Among authors: janzen wp. J Med Chem. 2012 Jul 26;55(14):6467-77. doi: 10.1021/jm3004834. Epub 2012 Jul 16. J Med Chem. 2012. PMID: 22738238 Free PMC article.
66 results