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Page 1
Targeted next-generation sequencing detects point mutations, insertions, deletions and balanced chromosomal rearrangements as well as identifies novel leukemia-specific fusion genes in a single procedure.
Grossmann V, Kohlmann A, Klein HU, Schindela S, Schnittger S, Dicker F, Dugas M, Kern W, Haferlach T, Haferlach C. Grossmann V, et al. Among authors: klein hu. Leukemia. 2011 Apr;25(4):671-80. doi: 10.1038/leu.2010.309. Epub 2011 Jan 21. Leukemia. 2011. PMID: 21252984
The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories.
Kohlmann A, Klein HU, Weissmann S, Bresolin S, Chaplin T, Cuppens H, Haschke-Becher E, Garicochea B, Grossmann V, Hanczaruk B, Hebestreit K, Gabriel C, Iacobucci I, Jansen JH, te Kronnie G, van de Locht L, Martinelli G, McGowan K, Schweiger MR, Timmermann B, Vandenberghe P, Young BD, Dugas M, Haferlach T. Kohlmann A, et al. Among authors: klein hu. Leukemia. 2011 Dec;25(12):1840-8. doi: 10.1038/leu.2011.155. Epub 2011 Jun 17. Leukemia. 2011. PMID: 21681191
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes.
Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G, Schnittger S, Sanada M, Kon A, Alpermann T, Yoshida K, Roller A, Nadarajah N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Kohlmann A, Miyano S, Haferlach C, Kern W, Ogawa S. Haferlach T, et al. Among authors: klein hu. Leukemia. 2014 Feb;28(2):241-7. doi: 10.1038/leu.2013.336. Epub 2013 Nov 13. Leukemia. 2014. PMID: 24220272 Free PMC article.
Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways.
Kohlmann A, Bullinger L, Thiede C, Schaich M, Schnittger S, Döhner K, Dugas M, Klein HU, Döhner H, Ehninger G, Haferlach T. Kohlmann A, et al. Among authors: klein hu. Leukemia. 2010 Jun;24(6):1216-20. doi: 10.1038/leu.2010.73. Epub 2010 Apr 29. Leukemia. 2010. PMID: 20428199 No abstract available.
Prognosis in patients with MDS or AML and bone marrow blasts between 10% and 30% is not associated with blast counts but depends on cytogenetic and molecular genetic characteristics.
Bacher U, Kern W, Alpermann T, Schnittger S, Kohlmann A, Klein HU, Dugas M, Haferlach C, Haferlach T. Bacher U, et al. Among authors: klein hu. Leukemia. 2011 Aug;25(8):1361-4. doi: 10.1038/leu.2011.80. Epub 2011 Apr 15. Leukemia. 2011. PMID: 21494258 No abstract available.
A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states.
Tuddenham JF, Taga M, Haage V, Marshe VS, Roostaei T, White C, Lee AJ, Fujita M, Khairallah A, Zhang Y, Green G, Hyman B, Frosch M, Hopp S, Beach TG, Serrano GE, Corboy J, Habib N, Klein HU, Soni RK, Teich AF, Hickman RA, Alcalay RN, Shneider N, Schneider J, Sims PA, Bennett DA, Olah M, Menon V, De Jager PL. Tuddenham JF, et al. Among authors: klein hu. Nat Neurosci. 2024 Dec;27(12):2521-2537. doi: 10.1038/s41593-024-01764-7. Epub 2024 Oct 15. Nat Neurosci. 2024. PMID: 39406950
Cellular communities reveal trajectories of brain ageing and Alzheimer's disease.
Green GS, Fujita M, Yang HS, Taga M, Cain A, McCabe C, Comandante-Lou N, White CC, Schmidtner AK, Zeng L, Sigalov A, Wang Y, Regev A, Klein HU, Menon V, Bennett DA, Habib N, De Jager PL. Green GS, et al. Among authors: klein hu. Nature. 2024 Sep;633(8030):634-645. doi: 10.1038/s41586-024-07871-6. Epub 2024 Aug 28. Nature. 2024. PMID: 39198642
254 results