Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice.
Murphy AJ, Macdonald LE, Stevens S, Karow M, Dore AT, Pobursky K, Huang TT, Poueymirou WT, Esau L, Meola M, Mikulka W, Krueger P, Fairhurst J, Valenzuela DM, Papadopoulos N, Yancopoulos GD.
Murphy AJ, et al. Among authors: valenzuela dm.
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5153-8. doi: 10.1073/pnas.1324022111. Epub 2014 Mar 25.
Proc Natl Acad Sci U S A. 2014.
PMID: 24706856
Free PMC article.