Jadhav V - Search Results

1

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape.

Bartz R, Fan H, Zhang J, Innocent N, Cherrin C, Beck SC, Pei Y, Momose A, Jadhav V, Tellers DM, Meng F, Crocker LS, Sepp-Lorenzino L, Barnett SF. Bartz R, et al. Among authors: jadhav v. Biochem J. 2011 Apr 15;435(2):475-87. doi: 10.1042/BJ20101021. Biochem J. 2011. PMID: 21265735

2

5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V. Parmar R, et al. Among authors: jadhav v. Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130. Epub 2016 Apr 28. Chembiochem. 2016. PMID: 27121751

3

Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment.

Abrams MT, Koser ML, Seitzer J, Williams SC, DiPietro MA, Wang W, Shaw AW, Mao X, Jadhav V, Davide JP, Burke PA, Sachs AB, Stirdivant SM, Sepp-Lorenzino L. Abrams MT, et al. Among authors: jadhav v. Mol Ther. 2010 Jan;18(1):171-80. doi: 10.1038/mt.2009.208. Epub 2009 Sep 8. Mol Ther. 2010. PMID: 19738601 Free PMC article.

4

Computational design and experimental characterization of peptides intended for pH-dependent membrane insertion and pore formation.

Zhang Y, Bartz R, Grigoryan G, Bryant M, Aaronson J, Beck S, Innocent N, Klein L, Procopio W, Tucker T, Jadhav V, Tellers DM, DeGrado WF. Zhang Y, et al. Among authors: jadhav v. ACS Chem Biol. 2015 Apr 17;10(4):1082-93. doi: 10.1021/cb500759p. Epub 2015 Jan 28. ACS Chem Biol. 2015. PMID: 25630033 Free PMC article.

5

Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation.

Ng B, Cash-Mason T, Wang Y, Seitzer J, Burchard J, Brown D, Dudkin V, Davide J, Jadhav V, Sepp-Lorenzino L, Cejas PJ. Ng B, et al. Among authors: jadhav v. Mol Ther Nucleic Acids. 2019 Jun 7;16:194-205. doi: 10.1016/j.omtn.2019.02.013. Epub 2019 Feb 26. Mol Ther Nucleic Acids. 2019. PMID: 30901578 Free PMC article.

6

Post-Synthetic Modification of Oligonucleotides via Orthogonal Amidation and Copper Catalyzed Cycloaddition Reactions.

Zewge D, Butora G, Sherer EC, Tellers DM, Sidler DR, Gouker J, Copeland G, Jadhav V, Li Z, Armstrong J, Davies IW. Zewge D, et al. Among authors: jadhav v. Bioconjug Chem. 2018 Jun 20;29(6):1859-1865. doi: 10.1021/acs.bioconjchem.8b00298. Epub 2018 Jun 12. Bioconjug Chem. 2018. PMID: 29893553

7

Centyrin ligands for extrahepatic delivery of siRNA.

Klein D, Goldberg S, Theile CS, Dambra R, Haskell K, Kuhar E, Lin T, Parmar R, Manoharan M, Richter M, Wu M, Mendrola Zarazowski J, Jadhav V, Maier MA, Sepp-Lorenzino L, O'Neil K, Dudkin V. Klein D, et al. Among authors: jadhav v. Mol Ther. 2021 Jun 2;29(6):2053-2066. doi: 10.1016/j.ymthe.2021.02.015. Epub 2021 Feb 15. Mol Ther. 2021. PMID: 33601052 Free PMC article.

8

Molecular umbrella conjugate for the ocular delivery of siRNA.

Janout V, Cline LL, Feuston BP, Klein L, O'Brien A, Tucker T, Yuan Y, O'Neill-Davis LA, Peiffer RL, Nerurkar SS, Jadhav V, Tellers DM, Regen SL. Janout V, et al. Among authors: jadhav v. Bioconjug Chem. 2014 Feb 19;25(2):197-201. doi: 10.1021/bc400506m. Epub 2014 Jan 23. Bioconjug Chem. 2014. PMID: 24433067 Free PMC article.

9

High-throughput chemical modification of oligonucleotides for systematic structure-activity relationship evaluation.

Zewge D, Gosselin F, Kenski DM, Li J, Jadhav V, Yuan Y, Nerurkar SS, Tellers DM, Flanagan WM, Davies IW. Zewge D, et al. Among authors: jadhav v. Bioconjug Chem. 2014 Dec 17;25(12):2222-32. doi: 10.1021/bc500453q. Epub 2014 Nov 21. Bioconjug Chem. 2014. PMID: 25398098

10

Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.

Khan T, Weber H, DiMuzio J, Matter A, Dogdas B, Shah T, Thankappan A, Disa J, Jadhav V, Lubbers L, Sepp-Lorenzino L, Strapps WR, Tadin-Strapps M. Khan T, et al. Among authors: jadhav v. Mol Ther Nucleic Acids. 2016 Aug 2;5(8):e342. doi: 10.1038/mtna.2016.55. Mol Ther Nucleic Acids. 2016. PMID: 27483025 Free PMC article.

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