Stabilization of IgG by supercritical fluid drying: optimization of formulation and process parameters.
Jovanović N, Bouchard A, Hofland GW, Witkamp GJ, Crommelin DJ, Jiskoot W.
Jovanović N, et al. Among authors: jiskoot w.
Eur J Pharm Biopharm. 2008 Feb;68(2):183-90. doi: 10.1016/j.ejpb.2007.05.001. Epub 2007 May 10.
Eur J Pharm Biopharm. 2008.
PMID: 17574824
Solutions containing IgG (20mg/ml) and trehalose or hydroxypropyl-beta-cyclodextrin in a 1:4 (w/w) ratio were sprayed into a SCF phase consisting of CO(2) and ethanol at 100bar and 37 degrees C. Initially, a set of drying conditions previously developed to successfu …
Solutions containing IgG (20mg/ml) and trehalose or hydroxypropyl-beta-cyclodextrin in a 1:4 (w/w) ratio were sprayed into a S …