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PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.
Kirchhof P, Kahr PC, Kaese S, Piccini I, Vokshi I, Scheld HH, Rotering H, Fortmueller L, Laakmann S, Verheule S, Schotten U, Fabritz L, Brown NA. Kirchhof P, et al. Among authors: verheule s. Circ Cardiovasc Genet. 2011 Apr;4(2):123-33. doi: 10.1161/CIRCGENETICS.110.958058. Epub 2011 Jan 31. Circ Cardiovasc Genet. 2011. PMID: 21282332
AVE0118, blocker of the transient outward current (I(to)) and ultrarapid delayed rectifier current (I(Kur)), fully restores atrial contractility after cardioversion of atrial fibrillation in the goat.
de Haan S, Greiser M, Harks E, Blaauw Y, van Hunnik A, Verheule S, Allessie M, Schotten U. de Haan S, et al. Among authors: verheule s. Circulation. 2006 Sep 19;114(12):1234-42. doi: 10.1161/CIRCULATIONAHA.106.630905. Epub 2006 Aug 28. Circulation. 2006. PMID: 16940189
Mechanisms of perpetuation of atrial fibrillation in chronically dilated atria.
Eckstein J, Verheule S, de Groot NM, Allessie M, Schotten U. Eckstein J, et al. Among authors: verheule s. Prog Biophys Mol Biol. 2008 Jun-Jul;97(2-3):435-51. doi: 10.1016/j.pbiomolbio.2008.02.019. Epub 2008 Feb 16. Prog Biophys Mol Biol. 2008. PMID: 18378284 Free article. Review.
Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.
Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U. Greiser M, et al. Among authors: verheule s. J Mol Cell Cardiol. 2009 Mar;46(3):385-94. doi: 10.1016/j.yjmcc.2008.11.012. Epub 2008 Nov 27. J Mol Cell Cardiol. 2009. PMID: 19100271
109 results