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Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.
Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T. Hata S, et al. Among authors: saftig p. J Biol Chem. 2009 Dec 25;284(52):36024-36033. doi: 10.1074/jbc.M109.057497. Epub 2009 Oct 28. J Biol Chem. 2009. PMID: 19864413 Free PMC article.
Role for LAMP-2 in endosomal cholesterol transport.
Schneede A, Schmidt CK, Hölttä-Vuori M, Heeren J, Willenborg M, Blanz J, Domanskyy M, Breiden B, Brodesser S, Landgrebe J, Sandhoff K, Ikonen E, Saftig P, Eskelinen EL. Schneede A, et al. Among authors: saftig p. J Cell Mol Med. 2011 Feb;15(2):280-95. doi: 10.1111/j.1582-4934.2009.00973.x. J Cell Mol Med. 2011. PMID: 19929948 Free PMC article.
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex.
Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, De Strooper B, Saftig P. Jorissen E, et al. Among authors: saftig p. J Neurosci. 2010 Apr 7;30(14):4833-44. doi: 10.1523/JNEUROSCI.5221-09.2010. J Neurosci. 2010. PMID: 20371803 Free PMC article.
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.
Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, Saftig P. Prox J, et al. Among authors: saftig p. J Neurosci. 2013 Aug 7;33(32):12915-28, 12928a. doi: 10.1523/JNEUROSCI.5910-12.2013. J Neurosci. 2013. PMID: 23926248 Free PMC article.
Cancer: Killing from the inside.
Saftig P, Sandhoff K. Saftig P, et al. Nature. 2013 Oct 17;502(7471):312-3. doi: 10.1038/nature12692. Epub 2013 Oct 2. Nature. 2013. PMID: 24089207 No abstract available.
Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.
Liebsch F, Kulic L, Teunissen C, Shobo A, Ulku I, Engelschalt V, Hancock MA, van der Flier WM, Kunach P, Rosa-Neto P, Scheltens P, Poirier J, Saftig P, Bateman RJ, Breitner J, Hock C, Multhaup G. Liebsch F, et al. Among authors: saftig p. Nat Commun. 2019 May 20;10(1):2240. doi: 10.1038/s41467-019-10152-w. Nat Commun. 2019. PMID: 31110178 Free PMC article.
346 results