Chorev M - Search Results

1

Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation.

Hoeffer CA, Cowansage KK, Arnold EC, Banko JL, Moerke NJ, Rodriguez R, Schmidt EK, Klosi E, Chorev M, Lloyd RE, Pierre P, Wagner G, LeDoux JE, Klann E. Hoeffer CA, et al. Among authors: chorev m. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3383-8. doi: 10.1073/pnas.1013063108. Epub 2011 Feb 2. Proc Natl Acad Sci U S A. 2011. PMID: 21289279 Free PMC article.

2

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.

Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G. Papadopoulos E, et al. Among authors: chorev m. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3187-95. doi: 10.1073/pnas.1410250111. Epub 2014 Jul 21. Proc Natl Acad Sci U S A. 2014. PMID: 25049413 Free PMC article.

3

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.

Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G. Moerke NJ, et al. Among authors: chorev m. Cell. 2007 Jan 26;128(2):257-67. doi: 10.1016/j.cell.2006.11.046. Cell. 2007. PMID: 17254965 Free article.

4

In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.

Denoyelle S, Chen T, Chen L, Wang Y, Klosi E, Halperin JA, Aktas BH, Chorev M. Denoyelle S, et al. Among authors: chorev m. Bioorg Med Chem Lett. 2012 Jan 1;22(1):402-9. doi: 10.1016/j.bmcl.2011.10.126. Epub 2011 Nov 16. Bioorg Med Chem Lett. 2012. PMID: 22153346 Free PMC article.

5

3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction.

Yefidoff-Freedman R, Chen T, Sahoo R, Chen L, Wagner G, Halperin JA, Aktas BH, Chorev M. Yefidoff-Freedman R, et al. Among authors: chorev m. Chembiochem. 2014 Mar 3;15(4):595-611. doi: 10.1002/cbic.201300723. Epub 2014 Jan 23. Chembiochem. 2014. PMID: 24458973 Free PMC article.

6

Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction.

Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M. Mahalingam P, et al. Among authors: chorev m. J Med Chem. 2014 Jun 26;57(12):5094-111. doi: 10.1021/jm401733v. Epub 2014 Jun 4. J Med Chem. 2014. PMID: 24827861 Free PMC article.

7

Tumor suppression by small molecule inhibitors of translation initiation.

Chen L, Aktas BH, Wang Y, He X, Sahoo R, Zhang N, Denoyelle S, Kabha E, Yang H, Freedman RY, Supko JG, Chorev M, Wagner G, Halperin JA. Chen L, et al. Among authors: chorev m. Oncotarget. 2012 Aug;3(8):869-81. doi: 10.18632/oncotarget.598. Oncotarget. 2012. PMID: 22935625 Free PMC article.

8

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.

Takrouri K, Chen T, Papadopoulos E, Sahoo R, Kabha E, Chen H, Cantel S, Wagner G, Halperin JA, Aktas BH, Chorev M. Takrouri K, et al. Among authors: chorev m. Eur J Med Chem. 2014 Apr 22;77:361-77. doi: 10.1016/j.ejmech.2014.03.034. Epub 2014 Mar 13. Eur J Med Chem. 2014. PMID: 24675136 Free PMC article.

9

Synthetic studies toward aryl-(4-aryl-4H-[1,2,4]triazole-3-yl)-amine from 1,3-diarylthiourea as urea mimetics.

Natarajan A, Guo Y, Arthanari H, Wagner G, Halperin JA, Chorev M. Natarajan A, et al. Among authors: chorev m. J Org Chem. 2005 Aug 5;70(16):6362-8. doi: 10.1021/jo0508189. J Org Chem. 2005. PMID: 16050698 Free PMC article.

10

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target.

Chen T, Ozel D, Qiao Y, Harbinski F, Chen L, Denoyelle S, He X, Zvereva N, Supko JG, Chorev M, Halperin JA, Aktas BH. Chen T, et al. Among authors: chorev m. Nat Chem Biol. 2011 Jul 17;7(9):610-6. doi: 10.1038/nchembio.613. Nat Chem Biol. 2011. PMID: 21765405 Free PMC article.

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