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Human neuroglobin functions as a redox-regulated nitrite reductase.
Tiso M, Tejero J, Basu S, Azarov I, Wang X, Simplaceanu V, Frizzell S, Jayaraman T, Geary L, Shapiro C, Ho C, Shiva S, Kim-Shapiro DB, Gladwin MT. Tiso M, et al. Among authors: wang x. J Biol Chem. 2011 May 20;286(20):18277-89. doi: 10.1074/jbc.M110.159541. Epub 2011 Feb 4. J Biol Chem. 2011. PMID: 21296891 Free PMC article.
14-3-3 binding and phosphorylation of neuroglobin during hypoxia modulate six-to-five heme pocket coordination and rate of nitrite reduction to nitric oxide.
Jayaraman T, Tejero J, Chen BB, Blood AB, Frizzell S, Shapiro C, Tiso M, Hood BL, Wang X, Zhao X, Conrads TP, Mallampalli RK, Gladwin MT. Jayaraman T, et al. Among authors: wang x. J Biol Chem. 2011 Dec 9;286(49):42679-42689. doi: 10.1074/jbc.M111.271973. Epub 2011 Sep 29. J Biol Chem. 2011. PMID: 21965683 Free PMC article.
Biological activity of nitric oxide in the plasmatic compartment.
Wang X, Tanus-Santos JE, Reiter CD, Dejam A, Shiva S, Smith RD, Hogg N, Gladwin MT. Wang X, et al. Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11477-82. doi: 10.1073/pnas.0402201101. Epub 2004 Jul 16. Proc Natl Acad Sci U S A. 2004. PMID: 15258287 Free PMC article. Clinical Trial.
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