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Dopamine induces IL-6-dependent IL-17 production via D1-like receptor on CD4 naive T cells and D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis/SCID mouse chimera model.
Nakano K, Yamaoka K, Hanami K, Saito K, Sasaguri Y, Yanagihara N, Tanaka S, Katsuki I, Matsushita S, Tanaka Y. Nakano K, et al. Among authors: tanaka s, tanaka y. J Immunol. 2011 Mar 15;186(6):3745-52. doi: 10.4049/jimmunol.1002475. Epub 2011 Feb 9. J Immunol. 2011. PMID: 21307293
Selective cyclooxygenase-2 inhibitor prevents reduction of trabecular bone mass in collagen-induced arthritic mice in association with suppression of RANKL/OPG ratio and IL-6 mRNA expression in synovial tissues but not in bone marrow cells.
Taketa T, Sakai A, Tanaka S, Nakai K, Menuki K, Yamane H, Tanaka K, Nakamura T. Taketa T, et al. Among authors: tanaka k, tanaka s. J Bone Miner Metab. 2008;26(2):143-51. doi: 10.1007/s00774-007-0808-2. Epub 2008 Feb 27. J Bone Miner Metab. 2008. PMID: 18301970
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