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Page 1
4''-O-(omega-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens.
Fajdetić A, Cipcić Paljetak H, Lazarevski G, Hutinec A, Alihodzić S, Derek M, Stimac V, Andreotti D, Sunjić V, Berge JM, Mutak S, Dumić M, Lociuro S, Holmes DJ, Marsić N, Eraković Haber V, Spaventi R. Fajdetić A, et al. Among authors: hutinec a. Bioorg Med Chem. 2010 Sep 1;18(17):6559-68. doi: 10.1016/j.bmc.2010.06.049. Epub 2010 Jun 22. Bioorg Med Chem. 2010. PMID: 20634078
Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin.
Perić M, Fajdetić A, Rupčić R, Alihodžić S, Ziher D, Bukvić Krajačić M, Smith KS, Ivezić-Schönfeld Z, Padovan J, Landek G, Jelić D, Hutinec A, Mesić M, Ager A, Ellis WY, Milhous WK, Ohrt C, Spaventi R. Perić M, et al. Among authors: hutinec a. J Med Chem. 2012 Feb 9;55(3):1389-401. doi: 10.1021/jm201615t. Epub 2012 Jan 25. J Med Chem. 2012. PMID: 22148880
Current Trends in Macrocyclic Drug Discovery and beyond-Ro5.
Alihodžić S, Bukvić M, Elenkov IJ, Hutinec A, Koštrun S, Pešić D, Saxty G, Tomašković L, Žiher D. Alihodžić S, et al. Among authors: hutinec a. Prog Med Chem. 2018;57(1):113-233. doi: 10.1016/bs.pmch.2018.01.002. Epub 2018 Mar 22. Prog Med Chem. 2018. PMID: 29680148 Review.
Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode.
Southall SM, Banerjee J, Brown J, Butkovic K, Cansfield AD, Cansfield JE, Congreve MS, Cseke G, Deflorian F, Hunjadi MP, Hutinec A, Inturi TK, Rupcic R, Saxty G, Watson SP. Southall SM, et al. Among authors: hutinec a. ACS Med Chem Lett. 2022 Oct 19;13(11):1776-1782. doi: 10.1021/acsmedchemlett.2c00400. eCollection 2022 Nov 10. ACS Med Chem Lett. 2022. PMID: 36385934 Free PMC article.
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
Cansfield AD, Ator MA, Banerjee J, Bestwick M, Bortolato A, Brown GA, Brown J, Butkovic K, Cansfield JE, Christopher JA, Congreve M, Cseke G, Deflorian F, Dugan B, Hunjadi MP, Hutinec A, Inturi TK, Landek G, Mason J, O'Brien A, Ott GR, Rupcic R, Saxty G, Southall SM, Zadravec R, Watson SP. Cansfield AD, et al. Among authors: hutinec a. ACS Chem Neurosci. 2022 Mar 16;13(6):751-765. doi: 10.1021/acschemneuro.1c00696. Epub 2022 Mar 4. ACS Chem Neurosci. 2022. PMID: 35245037