Nagpal K - Search Results

1

Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.

Nagpal K, Plantinga TS, Sirois CM, Monks BG, Latz E, Netea MG, Golenbock DT. Nagpal K, et al. J Biol Chem. 2011 Apr 1;286(13):11875-82. doi: 10.1074/jbc.M110.199653. Epub 2011 Feb 16. J Biol Chem. 2011. PMID: 21325272 Free PMC article.

2

A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.

Nagpal K, Plantinga TS, Wong J, Monks BG, Gay NJ, Netea MG, Fitzgerald KA, Golenbock DT. Nagpal K, et al. J Biol Chem. 2009 Sep 18;284(38):25742-8. doi: 10.1074/jbc.M109.014886. Epub 2009 Jun 9. J Biol Chem. 2009. PMID: 19509286 Free PMC article.

3

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.

Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ, Mansell A. Verstak B, et al. Among authors: nagpal k. J Biol Chem. 2009 Sep 4;284(36):24192-203. doi: 10.1074/jbc.M109.023044. Epub 2009 Jul 10. J Biol Chem. 2009. PMID: 19592497 Free PMC article.

4

TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.

Siednienko J, Halle A, Nagpal K, Golenbock DT, Miggin SM. Siednienko J, et al. Among authors: nagpal k. Eur J Immunol. 2010 Nov;40(11):3150-60. doi: 10.1002/eji.201040547. Epub 2010 Oct 19. Eur J Immunol. 2010. PMID: 20957750 Free article.

5

LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.

Tamehiro N, Park MH, Hawxhurst V, Nagpal K, Adams ME, Zannis VI, Golenbock DT, Fitzgerald ML. Tamehiro N, et al. Among authors: nagpal k. Biochemistry. 2015 Nov 24;54(46):6931-41. doi: 10.1021/acs.biochem.5b00894. Epub 2015 Nov 9. Biochemistry. 2015. PMID: 26506427 Free PMC article.

6

Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.

Andrade WA, Souza Mdo C, Ramos-Martinez E, Nagpal K, Dutra MS, Melo MB, Bartholomeu DC, Ghosh S, Golenbock DT, Gazzinelli RT. Andrade WA, et al. Among authors: nagpal k. Cell Host Microbe. 2013 Jan 16;13(1):42-53. doi: 10.1016/j.chom.2012.12.003. Epub 2013 Jan 3. Cell Host Microbe. 2013. PMID: 23290966 Free PMC article.

7

Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.

Lysakova-Devine T, Keogh B, Harrington B, Nagpal K, Halle A, Golenbock DT, Monie T, Bowie AG. Lysakova-Devine T, et al. Among authors: nagpal k. J Immunol. 2010 Oct 1;185(7):4261-71. doi: 10.4049/jimmunol.1002013. Epub 2010 Aug 27. J Immunol. 2010. PMID: 20802145

8

Transcription factor Ikaros represses protein phosphatase 2A (PP2A) expression through an intronic binding site.

Nagpal K, Watanabe KS, Tsao BP, Tsokos GC. Nagpal K, et al. J Biol Chem. 2014 May 16;289(20):13751-7. doi: 10.1074/jbc.M114.558197. Epub 2014 Apr 1. J Biol Chem. 2014. PMID: 24692537 Free PMC article.

9

The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway in T-cells from controls and systemic lupus erythematosus patients.

Sunahori K, Nagpal K, Hedrich CM, Mizui M, Fitzgerald LM, Tsokos GC. Sunahori K, et al. Among authors: nagpal k. J Biol Chem. 2013 Jul 26;288(30):21936-44. doi: 10.1074/jbc.M113.467266. Epub 2013 Jun 17. J Biol Chem. 2013. PMID: 23775084 Free PMC article.

10

The Regulatory Subunit PPP2R2A of PP2A Enhances Th1 and Th17 Differentiation through Activation of the GEF-H1/RhoA/ROCK Signaling Pathway.

Pan W, Nagpal K, Suárez-Fueyo A, Ferretti A, Yoshida N, Tsokos MG, Tsokos GC. Pan W, et al. Among authors: nagpal k. J Immunol. 2021 Apr 15;206(8):1719-1728. doi: 10.4049/jimmunol.2001266. Epub 2021 Mar 24. J Immunol. 2021. PMID: 33762326 Free PMC article.

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