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Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU. Schilling S, et al. Among authors: freyse ej. J Biol Chem. 2011 Apr 22;286(16):14199-208. doi: 10.1074/jbc.M111.229385. Epub 2011 Feb 17. J Biol Chem. 2011. PMID: 21330373 Free PMC article.
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU. Cynis H, et al. Among authors: freyse ej. EMBO Mol Med. 2011 Sep;3(9):545-58. doi: 10.1002/emmm.201100158. Epub 2011 Jul 20. EMBO Mol Med. 2011. PMID: 21774078 Free PMC article.
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
Becker A, Eichentopf R, Sedlmeier R, Waniek A, Cynis H, Koch B, Stephan A, Bäuscher C, Kohlmann S, Hoffmann T, Kehlen A, Berg S, Freyse EJ, Osmand A, Plank AC, Roßner S, von Hörsten S, Graubner S, Demuth HU, Schilling S. Becker A, et al. Among authors: freyse ej. Biol Chem. 2016 Jan;397(1):45-55. doi: 10.1515/hsz-2015-0192. Biol Chem. 2016. PMID: 26351917
Aptamer BC007 for neutralization of pathogenic autoantibodies directed against G-protein coupled receptors: A vision of future treatment of patients with cardiomyopathies and positivity for those autoantibodies.
Wallukat G, Müller J, Haberland A, Berg S, Schulz A, Freyse EJ, Vetter R, Salzsieder E, Kreutz R, Schimke I. Wallukat G, et al. Among authors: freyse ej. Atherosclerosis. 2016 Jan;244:44-7. doi: 10.1016/j.atherosclerosis.2015.11.001. Epub 2015 Nov 10. Atherosclerosis. 2016. PMID: 26584137
59 results